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Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil

Brazil is, at the time of writing, the global epicenter of COVID-19, but information on risk factors for hospitalization and mortality in the country is still limited. Demographic and clinical data of COVID-19 patients until June 11th, 2020 were retrieved from the State Health Secretariat of Espírit...

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Autores principales: Soares, Rita de Cássia Menezes, Mattos, Larissa Rodrigues, Raposo, Letícia Martins
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470570/
https://www.ncbi.nlm.nih.gov/pubmed/32682453
http://dx.doi.org/10.4269/ajtmh.20-0483
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author Soares, Rita de Cássia Menezes
Mattos, Larissa Rodrigues
Raposo, Letícia Martins
author_facet Soares, Rita de Cássia Menezes
Mattos, Larissa Rodrigues
Raposo, Letícia Martins
author_sort Soares, Rita de Cássia Menezes
collection PubMed
description Brazil is, at the time of writing, the global epicenter of COVID-19, but information on risk factors for hospitalization and mortality in the country is still limited. Demographic and clinical data of COVID-19 patients until June 11th, 2020 were retrieved from the State Health Secretariat of Espírito Santo, Brazil. Potential risk factors for COVID-19 hospitalization and death were analyzed by univariate and multivariable logistic regression models. A total of 10,713 COVID-19 patients were included in this study; 81.0% were younger than 60 years, 55.2% were female, 89.2% were not hospitalized, 32.9% had at least one comorbidity, and 7.7% died. The most common symptoms on admission were cough (67.7%) and fever (62.6%); 7.1% of the patients were asymptomatic. Cardiovascular diseases (23.7%) and diabetes (10.3%) were the two most common chronic diseases. Multivariate logistic regression analysis identified an association of all explanatory variables, except for cough and diarrhea, with hospitalization. Older age (odds ratio [OR] = 3.95, P < 0.001) and shortness of breath (OR = 3.55, P < 0.001) were associated with increase of odds to COVID-19 death in hospitalized patients. Our study provided evidence that older age, male gender, Asian, indigenous or unknown race, comorbidities (smoking, kidney disease, obesity, pulmonary disease, diabetes, and cardiovascular disease), as well as fever and shortness of breath increased the risk of hospitalization. For death outcome in hospitalized patients, only older age and shortness of breath increased the risk.
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spelling pubmed-74705702020-09-04 Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil Soares, Rita de Cássia Menezes Mattos, Larissa Rodrigues Raposo, Letícia Martins Am J Trop Med Hyg Articles Brazil is, at the time of writing, the global epicenter of COVID-19, but information on risk factors for hospitalization and mortality in the country is still limited. Demographic and clinical data of COVID-19 patients until June 11th, 2020 were retrieved from the State Health Secretariat of Espírito Santo, Brazil. Potential risk factors for COVID-19 hospitalization and death were analyzed by univariate and multivariable logistic regression models. A total of 10,713 COVID-19 patients were included in this study; 81.0% were younger than 60 years, 55.2% were female, 89.2% were not hospitalized, 32.9% had at least one comorbidity, and 7.7% died. The most common symptoms on admission were cough (67.7%) and fever (62.6%); 7.1% of the patients were asymptomatic. Cardiovascular diseases (23.7%) and diabetes (10.3%) were the two most common chronic diseases. Multivariate logistic regression analysis identified an association of all explanatory variables, except for cough and diarrhea, with hospitalization. Older age (odds ratio [OR] = 3.95, P < 0.001) and shortness of breath (OR = 3.55, P < 0.001) were associated with increase of odds to COVID-19 death in hospitalized patients. Our study provided evidence that older age, male gender, Asian, indigenous or unknown race, comorbidities (smoking, kidney disease, obesity, pulmonary disease, diabetes, and cardiovascular disease), as well as fever and shortness of breath increased the risk of hospitalization. For death outcome in hospitalized patients, only older age and shortness of breath increased the risk. The American Society of Tropical Medicine and Hygiene 2020-09 2020-07-16 /pmc/articles/PMC7470570/ /pubmed/32682453 http://dx.doi.org/10.4269/ajtmh.20-0483 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Soares, Rita de Cássia Menezes
Mattos, Larissa Rodrigues
Raposo, Letícia Martins
Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil
title Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil
title_full Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil
title_fullStr Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil
title_full_unstemmed Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil
title_short Risk Factors for Hospitalization and Mortality due to COVID-19 in Espírito Santo State, Brazil
title_sort risk factors for hospitalization and mortality due to covid-19 in espírito santo state, brazil
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470570/
https://www.ncbi.nlm.nih.gov/pubmed/32682453
http://dx.doi.org/10.4269/ajtmh.20-0483
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