Diagnosis of COVID-19 in a Dengue-Endemic Area

Emergence of SARS-CoV-2 in dengue virus (DENV)–endemic areas complicates the diagnosis of both infections. COVID-19 cases may be misdiagnosed as dengue, particularly when relying on DENV IgM, which can remain positive months after infection. To estimate the extent of this problem, we evaluated sera...

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Detalles Bibliográficos
Autores principales: Lokida, Dewi, Lukman, Nurhayati, Salim, Gustiani, Butar-butar, Deni Pepy, Kosasih, Herman, Wulan, Wahyu Nawang, Naysilla, Adhella Menur, Djajady, Yuanita, Sari, Rizki Amalia, Arlinda, Dona, Lau, Chuen-Yen, Karyana, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470577/
https://www.ncbi.nlm.nih.gov/pubmed/32762798
http://dx.doi.org/10.4269/ajtmh.20-0676
Descripción
Sumario:Emergence of SARS-CoV-2 in dengue virus (DENV)–endemic areas complicates the diagnosis of both infections. COVID-19 cases may be misdiagnosed as dengue, particularly when relying on DENV IgM, which can remain positive months after infection. To estimate the extent of this problem, we evaluated sera from 42 confirmed COVID-19 patients for evidence of DENV infection. No cases of SARS-CoV-2 and DENV coinfection were identified. However, recent DENV infection, indicated by the presence of DENV IgM and/or high level of IgG antibodies, was found in seven patients. Dengue virus IgM and/or high IgG titer should not exclude COVID-19. SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) testing is appropriate when dengue nonstructural protein 1 (NS1) or RT-PCR is negative. Given the possibility of coinfection, testing for both DENV and SARS-CoV-2 is merited in the setting of the current pandemic.

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