Metabolic excretion associated with nutrient–growth dysregulation promotes the rapid evolution of an overt metabolic defect

In eukaryotes, conserved mechanisms ensure that cell growth is coordinated with nutrient availability. Overactive growth during nutrient limitation (“nutrient–growth dysregulation”) can lead to rapid cell death. Here, we demonstrate that cells can adapt to nutrient–growth dysregulation by evolving m...

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Detalles Bibliográficos
Autores principales: Green, Robin, Sonal, Wang, Lin, Hart, Samuel F. M., Lu, Wenyun, Skelding, David, Burton, Justin C., Mi, Hanbing, Capel, Aric, Chen, Hung Alex, Lin, Aaron, Subramaniam, Arvind R., Rabinowitz, Joshua D., Shou, Wenying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470746/
https://www.ncbi.nlm.nih.gov/pubmed/32833957
http://dx.doi.org/10.1371/journal.pbio.3000757

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