MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes

The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a public health emergency of international concern as more than 15 million cases were reported by 24th July 2020. Angiotensin-converting enzyme 2 (ACE2) is a COVID-19 entry receptor regulating host cell infection. A...

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Autores principales: Lu, Dongchao, Chatterjee, Shambhabi, Xiao, Ke, Riedel, Isabelle, Wang, Yibin, Foo, Roger, Bär, Christian, Thum, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470794/
https://www.ncbi.nlm.nih.gov/pubmed/32891636
http://dx.doi.org/10.1016/j.yjmcc.2020.08.017
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author Lu, Dongchao
Chatterjee, Shambhabi
Xiao, Ke
Riedel, Isabelle
Wang, Yibin
Foo, Roger
Bär, Christian
Thum, Thomas
author_facet Lu, Dongchao
Chatterjee, Shambhabi
Xiao, Ke
Riedel, Isabelle
Wang, Yibin
Foo, Roger
Bär, Christian
Thum, Thomas
author_sort Lu, Dongchao
collection PubMed
description The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a public health emergency of international concern as more than 15 million cases were reported by 24th July 2020. Angiotensin-converting enzyme 2 (ACE2) is a COVID-19 entry receptor regulating host cell infection. A recent study reported that ACE2 is expressed in cardiomyocytes. In this study, we aimed to explore if there are microRNA (miRNA) molecules which target ACE2 and which may be exploited to regulate the SARS-CoV-2 receptor. Our data reveal that both Ace2 mRNA and Ace2 protein levels are inhibited by miR-200c in rat primary cardiomyocytes and importantly, in human iPSC-derived cardiomyocytes. We report the first miRNA candidate that can target ACE2 in cardiomyocytes and thus may be exploited as a preventive strategy to treat cardiovascular complications of COVID-19.
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spelling pubmed-74707942020-09-04 MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes Lu, Dongchao Chatterjee, Shambhabi Xiao, Ke Riedel, Isabelle Wang, Yibin Foo, Roger Bär, Christian Thum, Thomas J Mol Cell Cardiol Short Communication The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a public health emergency of international concern as more than 15 million cases were reported by 24th July 2020. Angiotensin-converting enzyme 2 (ACE2) is a COVID-19 entry receptor regulating host cell infection. A recent study reported that ACE2 is expressed in cardiomyocytes. In this study, we aimed to explore if there are microRNA (miRNA) molecules which target ACE2 and which may be exploited to regulate the SARS-CoV-2 receptor. Our data reveal that both Ace2 mRNA and Ace2 protein levels are inhibited by miR-200c in rat primary cardiomyocytes and importantly, in human iPSC-derived cardiomyocytes. We report the first miRNA candidate that can target ACE2 in cardiomyocytes and thus may be exploited as a preventive strategy to treat cardiovascular complications of COVID-19. The Authors. Published by Elsevier Ltd. 2020-11 2020-09-03 /pmc/articles/PMC7470794/ /pubmed/32891636 http://dx.doi.org/10.1016/j.yjmcc.2020.08.017 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Lu, Dongchao
Chatterjee, Shambhabi
Xiao, Ke
Riedel, Isabelle
Wang, Yibin
Foo, Roger
Bär, Christian
Thum, Thomas
MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
title MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
title_full MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
title_fullStr MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
title_full_unstemmed MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
title_short MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
title_sort micrornas targeting the sars-cov-2 entry receptor ace2 in cardiomyocytes
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470794/
https://www.ncbi.nlm.nih.gov/pubmed/32891636
http://dx.doi.org/10.1016/j.yjmcc.2020.08.017
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