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Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

TMEM16A Ca(2+)-activated chloride channel (CaCC) plays an essential role in vascular homeostasis. In this study we investigated the molecular mechanisms underlying downregulation of TMEM16A CaCC activity during hypertension. In cultured basilar artery smooth muscle cells (BASMCs) isolated from 2k2c...

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Detalles Bibliográficos
Autores principales:	Liu, Can-zhao, Li, Fei-ya, Lv, Xiao-fei, Ma, Ming-ming, Li, Xiang-yu, Lin, Cai-xia, Wang, Guan-lei, Guan, Yong-yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470808/ https://www.ncbi.nlm.nih.gov/pubmed/31484993 http://dx.doi.org/10.1038/s41401-019-0298-5

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