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A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score

BACKGROUND: Cytokine release storm (CRS) is a potentially fatal, hyperinflammatory condition common to both coronavirus disease 2019 (COVID-19) and reactive hemophagocytic lymphohistiocytosis (rHLH). We present our experience with the use of a diagnostic score, developed for rHLH, in a kidney transp...

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Autores principales: Adrogué, A.H., Mithani, F., Ibrahim, H.N., Schwartz, M.R., Gaber, L., Hebert, S.A., Adrogué, H.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470815/
https://www.ncbi.nlm.nih.gov/pubmed/32980137
http://dx.doi.org/10.1016/j.transproceed.2020.08.041
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author Adrogué, A.H.
Mithani, F.
Ibrahim, H.N.
Schwartz, M.R.
Gaber, L.
Hebert, S.A.
Adrogué, H.E.
author_facet Adrogué, A.H.
Mithani, F.
Ibrahim, H.N.
Schwartz, M.R.
Gaber, L.
Hebert, S.A.
Adrogué, H.E.
author_sort Adrogué, A.H.
collection PubMed
description BACKGROUND: Cytokine release storm (CRS) is a potentially fatal, hyperinflammatory condition common to both coronavirus disease 2019 (COVID-19) and reactive hemophagocytic lymphohistiocytosis (rHLH). We present our experience with the use of a diagnostic score, developed for rHLH, in a kidney transplant recipient hospitalized with COVID-19. METHODS: We applied the H-Score to risk-stratify our patient to help predict his hospital course. This study was exempt from requiring specific Institutional Review Board approval, but met all the criteria required by our institution for this type of study and report including consent from the patient. RESULTS: The calculated H-Score for our patient fell below the diagnostic cut-off value for rHLH. Because rHLH is characterized by CRS, we expected him to have a milder hospital course with COVID-19. Correlating with his below cut-off H-score, the patient had a more benign than expected hospital course. CONCLUSIONS: Because this is only a single case, we plan to retrospectively review a series of patients to validate our initial experience—that a low H-Score may correlate with a milder hospital course in kidney transplant patients with COVID-19.
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spelling pubmed-74708152020-09-04 A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score Adrogué, A.H. Mithani, F. Ibrahim, H.N. Schwartz, M.R. Gaber, L. Hebert, S.A. Adrogué, H.E. Transplant Proc COVID-19 Minisymposium: Towards a Strategic Roadmap BACKGROUND: Cytokine release storm (CRS) is a potentially fatal, hyperinflammatory condition common to both coronavirus disease 2019 (COVID-19) and reactive hemophagocytic lymphohistiocytosis (rHLH). We present our experience with the use of a diagnostic score, developed for rHLH, in a kidney transplant recipient hospitalized with COVID-19. METHODS: We applied the H-Score to risk-stratify our patient to help predict his hospital course. This study was exempt from requiring specific Institutional Review Board approval, but met all the criteria required by our institution for this type of study and report including consent from the patient. RESULTS: The calculated H-Score for our patient fell below the diagnostic cut-off value for rHLH. Because rHLH is characterized by CRS, we expected him to have a milder hospital course with COVID-19. Correlating with his below cut-off H-score, the patient had a more benign than expected hospital course. CONCLUSIONS: Because this is only a single case, we plan to retrospectively review a series of patients to validate our initial experience—that a low H-Score may correlate with a milder hospital course in kidney transplant patients with COVID-19. Elsevier Inc. 2020-11 2020-09-03 /pmc/articles/PMC7470815/ /pubmed/32980137 http://dx.doi.org/10.1016/j.transproceed.2020.08.041 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle COVID-19 Minisymposium: Towards a Strategic Roadmap
Adrogué, A.H.
Mithani, F.
Ibrahim, H.N.
Schwartz, M.R.
Gaber, L.
Hebert, S.A.
Adrogué, H.E.
A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score
title A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score
title_full A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score
title_fullStr A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score
title_full_unstemmed A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score
title_short A Kidney Transplant Recipient With Coronavirus Disease 2019: Utility of a Prognostication Score
title_sort kidney transplant recipient with coronavirus disease 2019: utility of a prognostication score
topic COVID-19 Minisymposium: Towards a Strategic Roadmap
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470815/
https://www.ncbi.nlm.nih.gov/pubmed/32980137
http://dx.doi.org/10.1016/j.transproceed.2020.08.041
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