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Light-induced engagement of microglia to focally remodel synapses in the adult brain

Microglia continuously monitor synapses, but active synaptic remodeling by microglia in mature healthy brains is rarely directly observed. We performed targeted photoablation of single synapses in mature transgenic mice expressing fluorescent labels in neurons and microglia. The photodamage focally...

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Detalles Bibliográficos
Autores principales: Cangalaya, Carla, Stoyanov, Stoyan, Fischer, Klaus-Dieter, Dityatev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470825/
https://www.ncbi.nlm.nih.gov/pubmed/32808923
http://dx.doi.org/10.7554/eLife.58435

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