Cargando…

The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as templates to catalyze SNARE complex assembly. Paradoxically, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eisemann, Travis J, Allen, Frederick, Lau, Kelly, Shimamura, Gregory R, Jeffrey, Philip D, Hughson, Frederick M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470827/ https://www.ncbi.nlm.nih.gov/pubmed/32804076 http://dx.doi.org/10.7554/eLife.60724

Ejemplares similares

The Sec1/Munc18 Protein Vps45 Regulates Cellular Levels of Its SNARE Binding Partners Tlg2 and Snc2 in Saccharomyces cerevisiae
por: Shanks, Scott G., et al.
Publicado: (2012)

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex
por: Lobingier, Braden T., et al.
Publicado: (2012)

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association
por: Jiao, Junyi, et al.
Publicado: (2018)

Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*
por: Baker, Richard W., et al.
Publicado: (2013)

The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes
por: Carpp, Lindsay N., et al.
Publicado: (2006)

The Tlg SNARE complex is required for TGN homotypic fusion
por: Brickner, Jason H., et al.
Publicado: (2001)

The Sec1p/Munc18 (SM) protein, Vps45p, cycles on and off membranes during vesicle transport
por: Bryant, Nia J., et al.
Publicado: (2003)

Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45
por: Roccisana, Jennifer, et al.
Publicado: (2013)

The Sec1p/Munc18 (SM) protein, Vps45p, cycles on and off membranes during vesicle transport
por: Bryant, Nia J., et al.
Publicado: (2012)

The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins
por: Bisio, Hugo, et al.
Publicado: (2020)

Sec1p Binds to Snare Complexes and Concentrates at Sites of Secretion
por: Carr, Chavela M., et al.
Publicado: (1999)

The Sec1–Munc18 protein VPS33B forms a uniquely bidirectional complex with VPS16B
por: Liu, Richard J.Y., et al.
Publicado: (2023)

The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans
por: Caza, Mélissa, et al.
Publicado: (2018)

SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18
por: Lobingier, Braden T, et al.
Publicado: (2014)

Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis
por: Xia, Tian, et al.
Publicado: (2012)

Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans
por: Solinger, Jachen A., et al.
Publicado: (2014)

Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B
por: Fu, Yuhui, et al.
Publicado: (2023)

CAPS and Munc13: CATCHRs that SNARE Vesicles
por: James, Declan J., et al.
Publicado: (2013)

Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1
por: Wang, Shen, et al.
Publicado: (2022)

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly
por: Lee, Sanghwa, et al.
Publicado: (2020)

Munc13 Mediates the Transition from the Closed Syntaxin–Munc18 complex to the SNARE complex
por: Ma, Cong, et al.
Publicado: (2011)

A Flexible Syntaxin Solves the Mystery of the SNAREd Munc
por: Robinson, Richard
Publicado: (2006)

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
por: Wang, Shen, et al.
Publicado: (2019)

Beyond the SNARE: Munc18-1 chaperones α-synuclein
por: Deshpande, Mugdha, et al.
Publicado: (2016)

A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13
por: Li, Yun, et al.
Publicado: (2017)

Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly
por: Rehman, Asma, et al.
Publicado: (2014)

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion
por: Boswell, Kristin L., et al.
Publicado: (2012)

Differential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE Complexes
por: Xu, Hao, et al.
Publicado: (2015)

A dynamic template complex mediates Munc18-chaperoned SNARE assembly
por: Yang, Jie, et al.
Publicado: (2022)

Structure of a Membrane Tethering Complex Incorporating Multiple SNAREs
por: DAmico, Kevin A., et al.
Publicado: (2023)

Efficient fusion requires a membrane anchor on the vacuolar Qa-SNARE
por: Wickner, William, et al.
Publicado: (2023)

Assembly-promoting protein Munc18c stimulates SNARE-dependent membrane fusion through its SNARE-like peptide
por: Liu, Furong, et al.
Publicado: (2022)

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
por: Deák, Ferenc, et al.
Publicado: (2009)

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis
por: Ma, Lu, et al.
Publicado: (2015)

Tyrosine phosphorylation of Munc18‐1 inhibits synaptic transmission by preventing SNARE assembly
por: Meijer, Marieke, et al.
Publicado: (2017)

Munc18-Bound Syntaxin Readily Forms SNARE Complexes with Synaptobrevin in Native Plasma Membranes
por: Zilly, Felipe E, et al.
Publicado: (2006)

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis
por: Jewell, Jenna L., et al.
Publicado: (2011)

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin
por: Zhang, Yunxiang, et al.
Publicado: (2015)

The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly
por: Rehman, Asma, et al.
Publicado: (2017)

Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles
por: Li, Feng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hud9aj0ib6rgev66c8lhd59sea