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Preclinical PK/PD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer

Previous studies show that dopamine D(2)-like receptor (D2DR) antagonist sulpiride (SUL) enhances the antitumor efficacy of dexamethasone (DEX) in drug-resistant breast cancer involving cancer stem-like cells (CSCs). In this study, we investigated the pharmacokinetic (PK) properties of SUL in nude m...

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Detalles Bibliográficos
Autores principales:	Yao, Qing-yu, Li, Jian, Chen, Rong, Yao, Ye, Xue, Jun-sheng, Chen, Wen-jun, Lu, Wei, Zhou, Tian-yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470835/ https://www.ncbi.nlm.nih.gov/pubmed/31165782 http://dx.doi.org/10.1038/s41401-019-0251-7

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