A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells

Natural compound valepotriate exhibits inhibitory activity against a number of cancers, but the effect of valepotriate against pancreatic cancer is unclear, and the structure–activity relationship of valepotriate has not been characterized. In this study, we performed a structure-based similarity se...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, You-you, Shi, Ke-yu, Teng, Fei, Chen, Jing, Che, Jin-xin, Dong, Xiao-wu, Lin, Neng-ming, Zhang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470838/
https://www.ncbi.nlm.nih.gov/pubmed/32047260
http://dx.doi.org/10.1038/s41401-019-0354-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470838/
https://www.ncbi.nlm.nih.gov/pubmed/32047260
http://dx.doi.org/10.1038/s41401-019-0354-1

Ejemplares similares