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A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells

Natural compound valepotriate exhibits inhibitory activity against a number of cancers, but the effect of valepotriate against pancreatic cancer is unclear, and the structure–activity relationship of valepotriate has not been characterized. In this study, we performed a structure-based similarity se...

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Detalles Bibliográficos
Autores principales:	Yan, You-you, Shi, Ke-yu, Teng, Fei, Chen, Jing, Che, Jin-xin, Dong, Xiao-wu, Lin, Neng-ming, Zhang, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470838/ https://www.ncbi.nlm.nih.gov/pubmed/32047260 http://dx.doi.org/10.1038/s41401-019-0354-1

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