Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells

PARK2, which encodes Parkin, is a disease-causing gene for both neurodegenerative disorders and cancer. Parkin can function as a neuroprotector that plays a crucial role in the regulation of mitophagy, and germline mutations in PARK2 are associated with Parkinson’s disease (PD). Intriguingly, recent...

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Detalles Bibliográficos
Autores principales: Zhang, Zeng-li, Wang, Na-na, Ma, Qi-lian, Chen, Yang, Yao, Li, Zhang, Li, Li, Qiu-shi, Shi, Min-hua, Wang, Hong-feng, Ying, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470868/
https://www.ncbi.nlm.nih.gov/pubmed/31285534
http://dx.doi.org/10.1038/s41401-019-0260-6

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