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Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism
We have recently developed an enzyme-directed immunostimulant (EDI) prodrug motif, which is metabolized to active immunostimulant by cancer cells and, following drug efflux, activates nearby immune cells, resulting in immunogenicity. In this study, we synthesized several EDI prodrugs featuring an im...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Singapore
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470892/ https://www.ncbi.nlm.nih.gov/pubmed/32451412 http://dx.doi.org/10.1038/s41401-020-0432-4 |