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Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

Deltex‐1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC)....

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Autores principales: Yoo, Seung Soo, Lee, Jang Hyuck, Hong, Mi Jeong, Choi, Jin Eun, Kang, Hyo‐Gyoung, Do, Sook Kyung, Kim, Ji Hyun, Baek, Sun Ah, Choi, Sun Ha, Lee, Won Kee, Lee, Yong Hoon, Seo, Hyewon, Lee, Jaehee, Lee, Shin Yup, Cha, Seung Ick, Kim, Chang Ho, Park, Jae Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471053/
https://www.ncbi.nlm.nih.gov/pubmed/32700476
http://dx.doi.org/10.1111/1759-7714.13566
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author Yoo, Seung Soo
Lee, Jang Hyuck
Hong, Mi Jeong
Choi, Jin Eun
Kang, Hyo‐Gyoung
Do, Sook Kyung
Kim, Ji Hyun
Baek, Sun Ah
Choi, Sun Ha
Lee, Won Kee
Lee, Yong Hoon
Seo, Hyewon
Lee, Jaehee
Lee, Shin Yup
Cha, Seung Ick
Kim, Chang Ho
Park, Jae Yong
author_facet Yoo, Seung Soo
Lee, Jang Hyuck
Hong, Mi Jeong
Choi, Jin Eun
Kang, Hyo‐Gyoung
Do, Sook Kyung
Kim, Ji Hyun
Baek, Sun Ah
Choi, Sun Ha
Lee, Won Kee
Lee, Yong Hoon
Seo, Hyewon
Lee, Jaehee
Lee, Shin Yup
Cha, Seung Ick
Kim, Chang Ho
Park, Jae Yong
author_sort Yoo, Seung Soo
collection PubMed
description Deltex‐1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10(−4); hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10(−7)). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: DTX1 rs1732786A > G was associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC) in our previous study. WHAT THIS STUDY ADDS: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC).
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spelling pubmed-74710532020-09-11 Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis Yoo, Seung Soo Lee, Jang Hyuck Hong, Mi Jeong Choi, Jin Eun Kang, Hyo‐Gyoung Do, Sook Kyung Kim, Ji Hyun Baek, Sun Ah Choi, Sun Ha Lee, Won Kee Lee, Yong Hoon Seo, Hyewon Lee, Jaehee Lee, Shin Yup Cha, Seung Ick Kim, Chang Ho Park, Jae Yong Thorac Cancer Brief Reports Deltex‐1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26–0.66, P = 2 × 10(−4); hazard ratio = 1.47, 95% CI: 1.17–1.84, P = 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P = 2 × 10(−7)). In summary, DTX1 rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: DTX1 rs1732786A > G was associated with better prognosis in patients with early‐stage non‐small cell lung cancer (NSCLC) in our previous study. WHAT THIS STUDY ADDS: DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC). John Wiley & Sons Australia, Ltd 2020-07-22 2020-09 /pmc/articles/PMC7471053/ /pubmed/32700476 http://dx.doi.org/10.1111/1759-7714.13566 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Brief Reports
Yoo, Seung Soo
Lee, Jang Hyuck
Hong, Mi Jeong
Choi, Jin Eun
Kang, Hyo‐Gyoung
Do, Sook Kyung
Kim, Ji Hyun
Baek, Sun Ah
Choi, Sun Ha
Lee, Won Kee
Lee, Yong Hoon
Seo, Hyewon
Lee, Jaehee
Lee, Shin Yup
Cha, Seung Ick
Kim, Chang Ho
Park, Jae Yong
Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
title Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
title_full Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
title_fullStr Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
title_full_unstemmed Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
title_short Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
title_sort effect of genetic variation in notch regulator dtx1 on sclc prognosis compared with the effect on nsclc prongosis
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471053/
https://www.ncbi.nlm.nih.gov/pubmed/32700476
http://dx.doi.org/10.1111/1759-7714.13566
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