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The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study

Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. The intraoperative diagnosis is important for guiding treatment decisions for patients with these co...

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Autores principales: Tanaka, Tomohito, Miyamoto, Shunsuke, Terada, Shinichi, Kogata, Yuhei, Fujiwara, Satoe, Tanaka, Yoshimichi, Taniguchi, Kohei, Komura, Kazumasa, Yamamoto, Kazuhiro, Yamada, Takashi, Ohmichi, Masahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471201/
https://www.ncbi.nlm.nih.gov/pubmed/32458294
http://dx.doi.org/10.1007/s12253-020-00822-2
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author Tanaka, Tomohito
Miyamoto, Shunsuke
Terada, Shinichi
Kogata, Yuhei
Fujiwara, Satoe
Tanaka, Yoshimichi
Taniguchi, Kohei
Komura, Kazumasa
Yamamoto, Kazuhiro
Yamada, Takashi
Ohmichi, Masahide
author_facet Tanaka, Tomohito
Miyamoto, Shunsuke
Terada, Shinichi
Kogata, Yuhei
Fujiwara, Satoe
Tanaka, Yoshimichi
Taniguchi, Kohei
Komura, Kazumasa
Yamamoto, Kazuhiro
Yamada, Takashi
Ohmichi, Masahide
author_sort Tanaka, Tomohito
collection PubMed
description Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. The intraoperative diagnosis is important for guiding treatment decisions for patients with these conditions. Three hundred seventy-one patients with cervical and endometrial cancer received SNB with an intraoperative frozen section analysis and imprint cytology. The sentinel node was cut in half, parallel to the longest axis, to obtain the maximum section area. After performing imprint cytology, one half was used to create a frozen section. The specimen was cut at 2-mm intervals into 5-μm-thick sections, which were subjected to hematoxylin and eosin staining. The diagnostic accuracy of intraoperative frozen section analyses and imprint cytology was compared to the final pathological diagnosis. Among 951 detected sentinel nodes, 51 nodes were found to be positive in the final pathological diagnosis. The sensitivity of a frozen section analysis, imprint cytology and the combination of the two modalities was 76.5%, 72.6%, and 92.2%, respectively. The specificity of a frozen section analysis and imprint cytology was 100%. The negative predictive value of a frozen section analysis and imprint cytology was 98.7% and 98.5%, respectively. In these settings, the accuracy of the frozen section analysis and imprint cytology in the evaluation of SNB specimens was considered acceptable; however, the sensitivity of the combined approach was higher in comparison to when a frozen section analysis or imprint cytology was performed alone.
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spelling pubmed-74712012020-09-16 The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study Tanaka, Tomohito Miyamoto, Shunsuke Terada, Shinichi Kogata, Yuhei Fujiwara, Satoe Tanaka, Yoshimichi Taniguchi, Kohei Komura, Kazumasa Yamamoto, Kazuhiro Yamada, Takashi Ohmichi, Masahide Pathol Oncol Res Original Article Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. The intraoperative diagnosis is important for guiding treatment decisions for patients with these conditions. Three hundred seventy-one patients with cervical and endometrial cancer received SNB with an intraoperative frozen section analysis and imprint cytology. The sentinel node was cut in half, parallel to the longest axis, to obtain the maximum section area. After performing imprint cytology, one half was used to create a frozen section. The specimen was cut at 2-mm intervals into 5-μm-thick sections, which were subjected to hematoxylin and eosin staining. The diagnostic accuracy of intraoperative frozen section analyses and imprint cytology was compared to the final pathological diagnosis. Among 951 detected sentinel nodes, 51 nodes were found to be positive in the final pathological diagnosis. The sensitivity of a frozen section analysis, imprint cytology and the combination of the two modalities was 76.5%, 72.6%, and 92.2%, respectively. The specificity of a frozen section analysis and imprint cytology was 100%. The negative predictive value of a frozen section analysis and imprint cytology was 98.7% and 98.5%, respectively. In these settings, the accuracy of the frozen section analysis and imprint cytology in the evaluation of SNB specimens was considered acceptable; however, the sensitivity of the combined approach was higher in comparison to when a frozen section analysis or imprint cytology was performed alone. Springer Netherlands 2020-05-26 2020 /pmc/articles/PMC7471201/ /pubmed/32458294 http://dx.doi.org/10.1007/s12253-020-00822-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Tanaka, Tomohito
Miyamoto, Shunsuke
Terada, Shinichi
Kogata, Yuhei
Fujiwara, Satoe
Tanaka, Yoshimichi
Taniguchi, Kohei
Komura, Kazumasa
Yamamoto, Kazuhiro
Yamada, Takashi
Ohmichi, Masahide
The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
title The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
title_full The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
title_fullStr The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
title_full_unstemmed The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
title_short The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
title_sort diagnostic accuracy of an intraoperative frozen section analysis and imprint cytology of sentinel node biopsy specimens from patients with uterine cervical and endometrial cancer: a retrospective observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471201/
https://www.ncbi.nlm.nih.gov/pubmed/32458294
http://dx.doi.org/10.1007/s12253-020-00822-2
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