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Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder

Impairment in verbal communication abilities has been reported in autism spectrum disorder (ASD). Dysfunction of the serotonergic system has also been reported in ASD. However, it is still unknown how the brain serotonergic system relates to impairment in verbal communication abilities in individual...

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Autores principales: Yoshimura, Yuko, Kikuchi, Mitsuru, Saito, Daisuke N., Hirosawa, Tetsu, Takahashi, Tetsuya, Munesue, Toshio, Kosaka, Hirotaka, Naito, Nobushige, Ouchi, Yasuomi, Minabe, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471326/
https://www.ncbi.nlm.nih.gov/pubmed/32883965
http://dx.doi.org/10.1038/s41598-020-71254-w
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author Yoshimura, Yuko
Kikuchi, Mitsuru
Saito, Daisuke N.
Hirosawa, Tetsu
Takahashi, Tetsuya
Munesue, Toshio
Kosaka, Hirotaka
Naito, Nobushige
Ouchi, Yasuomi
Minabe, Yoshio
author_facet Yoshimura, Yuko
Kikuchi, Mitsuru
Saito, Daisuke N.
Hirosawa, Tetsu
Takahashi, Tetsuya
Munesue, Toshio
Kosaka, Hirotaka
Naito, Nobushige
Ouchi, Yasuomi
Minabe, Yoshio
author_sort Yoshimura, Yuko
collection PubMed
description Impairment in verbal communication abilities has been reported in autism spectrum disorder (ASD). Dysfunction of the serotonergic system has also been reported in ASD. However, it is still unknown how the brain serotonergic system relates to impairment in verbal communication abilities in individuals with ASD. In the present study, we investigated the correlation between brain serotonergic condition and brain sensitivity to paralinguistic stimuli (i.e., amplitude in the human voice prosodic change-evoked mismatch field) measured by magnetoencephalography (MEG) or verbal ability in 10 adults with ASD. To estimate the brain serotonergic condition, we measured the serotonin transporter nondisplaceable binding potential cerebrum-wide using positron emission tomography with [11C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine ([11C] DASB). The results demonstrated a significant positive correlation between brain activity to paralinguistic stimuli and brain serotonin transporter binding potential in the left lingual gyrus, left fusiform gyrus and left calcarine cortex. In addition, there were significant positive correlations between verbal ability and serotonergic condition in the right anterior insula, right putamen and right central operculum. These results suggested that the occipital cortex is implicated in recognition of the prosodic change in ASD, whereas the right insula-involved serotonergic system is important in nurturing verbal function in ASD. Trial registration: UMIN000011077.
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spelling pubmed-74713262020-09-04 Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder Yoshimura, Yuko Kikuchi, Mitsuru Saito, Daisuke N. Hirosawa, Tetsu Takahashi, Tetsuya Munesue, Toshio Kosaka, Hirotaka Naito, Nobushige Ouchi, Yasuomi Minabe, Yoshio Sci Rep Article Impairment in verbal communication abilities has been reported in autism spectrum disorder (ASD). Dysfunction of the serotonergic system has also been reported in ASD. However, it is still unknown how the brain serotonergic system relates to impairment in verbal communication abilities in individuals with ASD. In the present study, we investigated the correlation between brain serotonergic condition and brain sensitivity to paralinguistic stimuli (i.e., amplitude in the human voice prosodic change-evoked mismatch field) measured by magnetoencephalography (MEG) or verbal ability in 10 adults with ASD. To estimate the brain serotonergic condition, we measured the serotonin transporter nondisplaceable binding potential cerebrum-wide using positron emission tomography with [11C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine ([11C] DASB). The results demonstrated a significant positive correlation between brain activity to paralinguistic stimuli and brain serotonin transporter binding potential in the left lingual gyrus, left fusiform gyrus and left calcarine cortex. In addition, there were significant positive correlations between verbal ability and serotonergic condition in the right anterior insula, right putamen and right central operculum. These results suggested that the occipital cortex is implicated in recognition of the prosodic change in ASD, whereas the right insula-involved serotonergic system is important in nurturing verbal function in ASD. Trial registration: UMIN000011077. Nature Publishing Group UK 2020-09-03 /pmc/articles/PMC7471326/ /pubmed/32883965 http://dx.doi.org/10.1038/s41598-020-71254-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yoshimura, Yuko
Kikuchi, Mitsuru
Saito, Daisuke N.
Hirosawa, Tetsu
Takahashi, Tetsuya
Munesue, Toshio
Kosaka, Hirotaka
Naito, Nobushige
Ouchi, Yasuomi
Minabe, Yoshio
Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
title Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
title_full Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
title_fullStr Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
title_full_unstemmed Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
title_short Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
title_sort markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471326/
https://www.ncbi.nlm.nih.gov/pubmed/32883965
http://dx.doi.org/10.1038/s41598-020-71254-w
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