Cargando…

Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ

Renal fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). Recently, asiatic acid (AA), a triterpenoid compound from Chinese medicine Centella asiatica, has been found to attenuate renal fibrosis. In the current study, we explored the mechanisms underlying anti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhi-hao, He, Jun-qiu, Zhao, Ying-yong, Chen, Hua-chao, Tan, Ning-hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471452/ https://www.ncbi.nlm.nih.gov/pubmed/31705123 http://dx.doi.org/10.1038/s41401-019-0319-4

Ejemplares similares

15-Deoxy-∆-(12,14)-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism
por: Li, Jingjing, et al.
Publicado: (2019)

Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction
por: Paulitschke, Verena, et al.
Publicado: (2012)

Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice
por: Bai, Yu, et al.
Publicado: (2020)

DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
por: Li, Xiaozhou, et al.
Publicado: (2020)

Intranasal 15d-PGJ2 inhibits the growth of rat lactotroph pituitary neuroendocrine tumors by inducing PPARγ-dependent apoptotic and autophagic cell death
por: Li, Zongyang, et al.
Publicado: (2023)

Transcriptome Identified lncRNAs Associated with Renal Fibrosis in UUO Rat Model
por: Sun, Jiazeng, et al.
Publicado: (2017)

Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage
por: Liao, Xiaohua, et al.
Publicado: (2022)

Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy
por: Liu, Bohao, et al.
Publicado: (2022)

Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3
por: Steinmetz-Späh, Julia, et al.
Publicado: (2022)

Corni Fructus Alleviates UUO-Induced Renal Fibrosis via TGF-β/Smad Signaling
por: Lee, Jin A., et al.
Publicado: (2022)

Nutraceuticals as Ligands of PPARγ
por: Penumetcha, Meera, et al.
Publicado: (2012)

Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats
por: Yu, Hang-Xing, et al.
Publicado: (2021)

Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells
por: Chen, Ling, et al.
Publicado: (2015)

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway
por: Liao, Yuan, et al.
Publicado: (2020)

15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells
por: Xiang, Zhongmin, et al.
Publicado: (2007)

Putative endothelial progenitor cells do not promote vascular repair but attenuate pericyte–myofibroblast transition in UUO-induced renal fibrosis
por: Yang, Juan, et al.
Publicado: (2019)

15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice
por: Ruiz-Miyazawa, Kenji W., et al.
Publicado: (2018)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases
por: Arvaniti, Eleni, et al.
Publicado: (2016)

Effects of PPARγ Ligands on Leukemia
por: Tabe, Yoko, et al.
Publicado: (2012)

Gastrointestinal Cytoprotection by PPARγ Ligands
por: Naito, Yuji, et al.
Publicado: (2010)

Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition
por: Xiong, Yunzhao, et al.
Publicado: (2021)

The 15d-PGJ(2) hydrogel ameliorates atopic dermatitis through suppression of the immune response
por: Napimoga, Marcelo H., et al.
Publicado: (2019)

Clinical Use of PPARγ Ligands in Cancer
por: Hatton, Jennifer L., et al.
Publicado: (2008)

An alternate binding site for PPARγ ligands
por: Hughes, Travis S., et al.
Publicado: (2014)

CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis
por: Yi, Lei, et al.
Publicado: (2021)

Synthetic Non-Coding RNA for Suppressing mTOR Translation to Prevent Renal Fibrosis Related to Autophagy in UUO Mouse Model
por: Kim, Young-Ah, et al.
Publicado: (2022)

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ
por: Shang, Jinsai, et al.
Publicado: (2018)

Infusion of Phagocytic Macrophages Overexpressing CPT1a Ameliorates Kidney Fibrosis in the UUO Model
por: Calle, Priscila, et al.
Publicado: (2021)

Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1
por: Cruz-Orengo, Lillian, et al.
Publicado: (2008)

Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion
por: Abbasi, Saed, et al.
Publicado: (2016)

Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models
por: Yuan, Jing, et al.
Publicado: (2017)

Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1
por: Ai, Kai, et al.
Publicado: (2022)

Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands
por: Eom, So Hyeon, et al.
Publicado: (2016)

PPARα/γ-Independent Effects of PPARα/γ Ligands on Cysteinyl Leukotriene Production in Mast Cells
por: Yamashita, Masamichi
Publicado: (2008)

Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylation
por: Chen, Dan-Qian, et al.
Publicado: (2022)

PPARγ Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
por: Han, Jee-Young, et al.
Publicado: (2010)

Nephropathy 1st inhibits renal fibrosis by activating the PPARγ signaling pathway
por: Mu, Linjie, et al.
Publicado: (2022)

Ligand Modulated Antagonism of PPARγ by Genomic and Non-Genomic Actions of PPARδ
por: Gustafsson, Mattias C. U., et al.
Publicado: (2009)

RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice
por: Zhou, Zhuanli, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1rt6vaga7jft31hft5v8j4kjdh