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Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats
Leptin resistance in endothelial cells leads to vascular endothelial dysfunction, which is the beginning and crucial link of atherosclerosis. However, the mechanism of leptin resistance remains obscure. Acid sphingomyelinase (ASM) catalyzes the hydrolysis of sphingomyelin to produce ceramide, which...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Singapore
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471453/ https://www.ncbi.nlm.nih.gov/pubmed/31848475 http://dx.doi.org/10.1038/s41401-019-0328-3 |