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Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

Cadmium (Cd) is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues (ECTs). In contrast, zinc (Zn) is a potent metallothionein (MT) inducer, which plays an important role in pro...

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Detalles Bibliográficos
Autores principales: Yu, Hai-tao, Zhen, Juan, Xu, Jian-xiang, Cai, Lu, Leng, Ji-yan, Ji, Hong-lei, Keller, Bradley B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471469/
https://www.ncbi.nlm.nih.gov/pubmed/31768045
http://dx.doi.org/10.1038/s41401-019-0320-y