Cargando…

An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

Spermatozoa released from the testis are unable to fertilize an egg without a coordinated process of maturation in the lumen of the epididymis. Relatively little is known about the molecular events that integrate this critical progression along the male genital ducts in man. Here, we use single cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leir, Shih-Hsing, Yin, Shiyi, Kerschner, Jenny L, Cosme, Wilmel, Harris, Ann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471510/ https://www.ncbi.nlm.nih.gov/pubmed/32855272 http://dx.doi.org/10.26508/lsa.202000744

Ejemplares similares

Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia
por: Paranjapye, Alekh, et al.
Publicado: (2022)

Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells
por: NandyMazumdar, Monali, et al.
Publicado: (2020)

Region-specific microRNA signatures in the human epididymis
por: Browne, James A, et al.
Publicado: (2018)

BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression
por: NandyMazumdar, Monali, et al.
Publicado: (2021)

A functional genomics approach to investigate the differentiation of iPSCs into lung epithelium at air‐liquid interface
por: Kerschner, Jenny L., et al.
Publicado: (2020)

Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus
por: Yang, Rui, et al.
Publicado: (2016)

Nucleosome occupancy reveals regulatory elements of the CFTR promoter
por: Ott, Christopher J., et al.
Publicado: (2012)

Nucleosome mapping across the CFTR locus identifies novel regulatory factors
por: Yigit, Erbay, et al.
Publicado: (2013)

Molecular mechanisms controlling CFTR gene expression in the airway
por: Zhang, Zhaolin, et al.
Publicado: (2012)

Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus
por: Gosalia, Nehal, et al.
Publicado: (2014)

Transcriptomic analysis of lung development in wildtype and CFTR(−/−) sheep suggests an early inflammatory signature in the CF distal lung
por: Kerschner, Jenny L., et al.
Publicado: (2023)

Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region
por: Swahn, Hannah, et al.
Publicado: (2019)

Enhancement of airway epithelial cell differentiation by pulmonary endothelial cell co-culture
por: Burkhanova, Umida, et al.
Publicado: (2022)

Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity
por: Stolzenburg, Lindsay R., et al.
Publicado: (2017)

An Optimized Protocol for Isolating Primary Epithelial Cell Chromatin for ChIP
por: Browne, James A., et al.
Publicado: (2014)

Transcriptome profiling of the initial segment and proximal caput of mouse epididymis
por: Wang, Xiao, et al.
Publicado: (2023)

Cross-talk between enhancers, structural elements and activating transcription factors maintains the 3D architecture and expression of the CFTR gene
por: Yin, Shiyi, et al.
Publicado: (2022)

An atlas of cell types in the mouse epididymis and vas deferens
por: Rinaldi, Vera D, et al.
Publicado: (2020)

Early developmental phenotypes in the cystic fibrosis sheep model
por: Van Wettere, Arnaud J., et al.
Publicado: (2022)

Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells
por: Paranjapye, Alekh, et al.
Publicado: (2021)

Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects
por: Ensinck, Marjolein, et al.
Publicado: (2020)

Malacoplakia of the Epididymis
por: Kang, Yu Jin, et al.
Publicado: (2013)

Xanthogranuloma of the epididymis
por: Ting, James, et al.
Publicado: (2018)

Testis and Epididymis
Publicado: (2007)

Proximity Profiling of the CFTR Interaction Landscape in Response to Orkambi
por: Iazzi, Melissa, et al.
Publicado: (2022)

Dual SMAD inhibition enhances the longevity of human epididymis epithelial cells
por: Coatti, Giuliana C., et al.
Publicado: (2022)

Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
por: Kechida, Melek, et al.
Publicado: (2022)

Transcriptional Specificity Analysis of Testis and Epididymis Tissues in Donkey
por: Yu, Mubin, et al.
Publicado: (2022)

Dissociation of Testis and Epididymis
Publicado: (1927)

Papillary cystadenoma of the epididymis
por: Lopez, Olga, et al.
Publicado: (2022)

Diseases of the Epididymis and Testicle
por: Morton, Henry H.
Publicado: (1916)

Chromatin Dynamics in the Regulation of CFTR Expression
por: Gosalia, Nehal, et al.
Publicado: (2015)

Collagen XV Inhibits Epithelial to Mesenchymal Transition in Pancreatic Adenocarcinoma Cells
por: Clementz, Anthony G., et al.
Publicado: (2013)

Cellular heterogeneity in the 16HBE14o (−) airway epithelial line impacts biological readouts
por: Kerschner, Jenny L., et al.
Publicado: (2023)

Study on the region-specific expression of epididymis mRNA in the rams
por: Wu, Cuiling, et al.
Publicado: (2021)

Targeted Inactivation of the Androgen Receptor Gene in Murine Proximal Epididymis Causes Epithelial Hypotrophy and Obstructive Azoospermia
por: Krutskikh, Anton, et al.
Publicado: (2011)

The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis
por: Kim, Bongki, et al.
Publicado: (2015)

Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells
por: Bene, Zsolt, et al.
Publicado: (2021)

Smooth muscle hyperplasia of the epididymis
por: Blach, O, et al.
Publicado: (2011)

Discutient Application to the Indurated Epididymis
Publicado: (1859)

Cannot write session to /tmp/vufind_sessions/sess_ov87hg6ebcbv66flshjvveuqd0