Cargando…
A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition
The activated B-cell (ABC) to plasmablast transition encompasses the cusp of antibody-secreting cell (ASC) differentiation. We explore this transition with integrated analysis in human cells, focusing on changes that follow removal from CD40-mediated signals. Within hours of input signal loss, cell...
Autores principales: | Cocco, Mario, Care, Matthew A, Saadi, Amel, Al-Maskari, Muna, Doody, Gina, Tooze, Reuben |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471511/ https://www.ncbi.nlm.nih.gov/pubmed/32843533 http://dx.doi.org/10.26508/lsa.202000654 |
Ejemplares similares
-
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
por: Al-Maskari, Muna, et al.
Publicado: (2018) -
Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition
por: Arumugakani, Gururaj, et al.
Publicado: (2017) -
Spontaneous EBV-Reactivation during B Cell Differentiation as a Model for Polymorphic EBV-Driven Lymphoproliferation
por: Care, Matthew A., et al.
Publicado: (2023) -
APRIL Drives a Coordinated but Diverse Response as a Foundation for Plasma Cell Longevity
por: Stephenson, Sophie, et al.
Publicado: (2022) -
Growth Factor–like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells
por: Stephenson, Sophie, et al.
Publicado: (2019)