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Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma

The basic helix-loop-helix (bHLH) transcription factors are negatively regulated by inhibitor of DNA-binding (ID) proteins. Several studies have demonstrated that ID family proteins are dysregulated in a variety of cancer types, including in lung adenocarcinoma (LUAD). In current study, the prognost...

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Autores principales: Lu, Xiaomin, Shao, Lili, Qian, Ye, Zhang, Yan, Wang, Yongsheng, Miao, Liyun, Zhuang, Zhixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471671/
https://www.ncbi.nlm.nih.gov/pubmed/32934711
http://dx.doi.org/10.3892/ol.2020.12004
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author Lu, Xiaomin
Shao, Lili
Qian, Ye
Zhang, Yan
Wang, Yongsheng
Miao, Liyun
Zhuang, Zhixiang
author_facet Lu, Xiaomin
Shao, Lili
Qian, Ye
Zhang, Yan
Wang, Yongsheng
Miao, Liyun
Zhuang, Zhixiang
author_sort Lu, Xiaomin
collection PubMed
description The basic helix-loop-helix (bHLH) transcription factors are negatively regulated by inhibitor of DNA-binding (ID) proteins. Several studies have demonstrated that ID family proteins are dysregulated in a variety of cancer types, including in lung adenocarcinoma (LUAD). In current study, the prognostic value of ID family members was evaluated by investigating publicly accessible databases, including Oncomine, Kaplan-Meier plotter, UALCAN and the Human Protein Atlas. It was observed that the mRNA expression of all ID members was downregulated in LUAD tumor tissues compared with those in normal tissues according to the Oncomine and UALCAN databases. Additionally, increased mRNA expression levels of ID2 and ID1 were associated with improved and poorer survival time, respectively. Notably, ID3 and ID4 expression was not associated with survival in patients with LUAD. At the protein level, high ID2 significantly predicted an improved survival outcome while high ID1 is associated with shorter survival time. Thus, the results indicate that the ID proteins, particularly ID2, exhibit significant prognostic value in LUAD. More studies are required to elucidate the underlying molecular mechanisms behind the role of the ID family in the development of LUAD.
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spelling pubmed-74716712020-09-14 Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma Lu, Xiaomin Shao, Lili Qian, Ye Zhang, Yan Wang, Yongsheng Miao, Liyun Zhuang, Zhixiang Oncol Lett Articles The basic helix-loop-helix (bHLH) transcription factors are negatively regulated by inhibitor of DNA-binding (ID) proteins. Several studies have demonstrated that ID family proteins are dysregulated in a variety of cancer types, including in lung adenocarcinoma (LUAD). In current study, the prognostic value of ID family members was evaluated by investigating publicly accessible databases, including Oncomine, Kaplan-Meier plotter, UALCAN and the Human Protein Atlas. It was observed that the mRNA expression of all ID members was downregulated in LUAD tumor tissues compared with those in normal tissues according to the Oncomine and UALCAN databases. Additionally, increased mRNA expression levels of ID2 and ID1 were associated with improved and poorer survival time, respectively. Notably, ID3 and ID4 expression was not associated with survival in patients with LUAD. At the protein level, high ID2 significantly predicted an improved survival outcome while high ID1 is associated with shorter survival time. Thus, the results indicate that the ID proteins, particularly ID2, exhibit significant prognostic value in LUAD. More studies are required to elucidate the underlying molecular mechanisms behind the role of the ID family in the development of LUAD. D.A. Spandidos 2020-11 2020-08-21 /pmc/articles/PMC7471671/ /pubmed/32934711 http://dx.doi.org/10.3892/ol.2020.12004 Text en Copyright: © Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Lu, Xiaomin
Shao, Lili
Qian, Ye
Zhang, Yan
Wang, Yongsheng
Miao, Liyun
Zhuang, Zhixiang
Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma
title Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma
title_full Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma
title_fullStr Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma
title_full_unstemmed Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma
title_short Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma
title_sort prognostic effects of the expression of inhibitor of dna-binding family members on patients with lung adenocarcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471671/
https://www.ncbi.nlm.nih.gov/pubmed/32934711
http://dx.doi.org/10.3892/ol.2020.12004
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