Cargando…

hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye

The present study was set out to address the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles (hADSC-Evs) in a mouse model of dry eye disease and to investigate the underlying mechanisms involved. hADSC-Evs eye drops were topically administered to mice that subj...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Chaoqun, Chen, Peng, Xu, Jing, Liu, Yaning, Li, Hui, Wang, Linna, Di, Guohu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471690/ https://www.ncbi.nlm.nih.gov/pubmed/32884023 http://dx.doi.org/10.1038/s41598-020-71337-8

Ejemplares similares

Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration
por: Zhou, Yang, et al.
Publicado: (2021)

Identification and characterization of hADSC‐derived exosome proteins from different isolation methods
por: Huang, Lien‐Hung, et al.
Publicado: (2021)

Rebuilding hippocampus neural circuit with hADSC-derived neuron cells for treating ischemic stroke
por: Wang, Jian, et al.
Publicado: (2022)

Modulation of Adipogenic Conditions for Prospective Use of hADSCs in Adipose Tissue Engineering
por: Galateanu, Bianca, et al.
Publicado: (2012)

Effects of RPE-conditioned medium on the differentiation of hADSCs into RPE cells, and their proliferation and migration
por: Zhang, Yi, et al.
Publicado: (2017)

Sericin Enhances the Bioperformance of Collagen-Based Matrices Preseeded with Human-Adipose Derived Stem Cells (hADSCs)
por: Dinescu, Sorina, et al.
Publicado: (2013)

TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway
por: Luan, Xiaoyu, et al.
Publicado: (2023)

PAC1R agonist maxadilan enhances hADSC viability and neural differentiation potential
por: Guo, Xiaoling, et al.
Publicado: (2016)

Microtissues Enhance Smooth Muscle Differentiation and Cell Viability of hADSCs for Three Dimensional Bioprinting
por: Yipeng, Jin, et al.
Publicado: (2017)

Directional Osteo-Differentiation Effect of hADSCs on Nanotopographical Self-Assembled Polystyrene Nanopit Surfaces
por: Zhao, Changhong, et al.
Publicado: (2020)

Perilipin Expression Reveals Adipogenic Potential of hADSCs inside Superporous Polymeric Cellular Delivery Systems
por: Dinescu, Sorina, et al.
Publicado: (2014)

Corrigendum: Microtissues Enhance Smooth Muscle Differentiation and Cell Viability of hADSCs for Three Dimensional Bioprinting
por: Jin, Yipeng, et al.
Publicado: (2017)

CD44 and HAP‐Conjugated hADSCs as Living Materials for Targeted Tumor Therapy and Bone Regeneration
por: Xia, He, et al.
Publicado: (2023)

Therapeutic effects of human adipose tissue-derived stem cell (hADSC) transplantation on experimental autoimmune encephalomyelitis (EAE) mice
por: Li, Jia, et al.
Publicado: (2017)

Discovery of Lactoferrin as a Stimulant for hADSC-Derived EV Secretion and Proof of Enhancement of Resulting EVs through Skin Model
por: Kim, Junho, et al.
Publicado: (2021)

Intratesticular Human Adipose-Derived Stem Cell (hADSC) Transplantation Decreased Oxidative Stress in Testicular Torsion Model of Wistar Rat
por: Siregar, Safendra, et al.
Publicado: (2021)

RAB37 Promotes Adipogenic Differentiation of hADSCs via the TIMP1/CD63/Integrin Signaling Pathway
por: Huang, Haili, et al.
Publicado: (2021)

The Role of the NLRP3 Inflammasome and Programmed Cell Death in Acute Liver Injury
por: Yu, Chaoqun, et al.
Publicado: (2023)

Synergistic interaction of hTGF-β(3) with hBMP-6 promotes articular cartilage formation in chitosan scaffolds with hADSCs: implications for regenerative medicine
por: Huang, Yijiang, et al.
Publicado: (2020)

Role of human adipose-derived stem cells (hADSC) on TGF-β1, type I collagen, and fibrosis degree in bladder obstruction model of Wistar rats
por: Siregar, Safendra, et al.
Publicado: (2022)

In vivo Confocal Microscopic Evaluation of Corneal Dendritic Cell Density and Subbasal Nerve Parameters in Dry Eye Patients: A Systematic Review and Meta-analysis
por: Xu, Jing, et al.
Publicado: (2021)

Autophagy regulates the effects of ADSC-derived small extracellular vesicles on acute lung injury
por: Li, Chichi, et al.
Publicado: (2022)

Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients
por: Niu, Liangliang, et al.
Publicado: (2015)

NLRP3 Inflammasome as a Potential Therapeutic Target in Dry Eye Disease
por: Zhuang, Dian, et al.
Publicado: (2023)

Extracellular vesicles derived from head and neck squamous cells carcinoma inhibit NLRP3 inflammasomes
por: Bottino, Luiza Zainotti Miguel Fahur, et al.
Publicado: (2021)

Effect of Intracorporeal Human Adipose–Derived Stem Cells (hADSCs) on Corpora Cavernosa Transforming Growth Factor β(1) (TGFβ(1)) and Collagen Type I Concentration in Wistar Rat Priapism Model
por: Siregar, Safendra, et al.
Publicado: (2020)

Corneal Epithelium–Derived Netrin-1 Alleviates Dry Eye Disease via Regulating Dendritic Cell Activation
por: Yu, Chaoqun, et al.
Publicado: (2022)

Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration
por: Roballo, Kelly Cristine Santos, et al.
Publicado: (2019)

Expression Profiles of CircRNA and mRNA in Lacrimal Glands of AQP5(–/–) Mice With Primary Dry Eye
por: Liu, Yaning, et al.
Publicado: (2020)

Mesenchymal Stromal Cells-Derived Extracellular Vesicles Regulate Dendritic Cell Functions in Dry Eye Disease
por: Guo, Rongjie, et al.
Publicado: (2022)

Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands
por: Cao, Xin, et al.
Publicado: (2023)

Lysosomal regulation of extracellular vesicle excretion during D-ribose-induced NLRP3 inflammasome activation in podocytes
por: Hong, Jinni, et al.
Publicado: (2019)

Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke
por: Kerr, Nadine, et al.
Publicado: (2018)

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome
por: Wang, Guozhen, et al.
Publicado: (2021)

Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation
por: Zhang, Chi, et al.
Publicado: (2022)

Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway
por: Park, Bongkyun, et al.
Publicado: (2019)

Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation
por: Yuan, Xinxu, et al.
Publicado: (2020)

Extracellular Acidification Augments NLRP3-Mediated Inflammasome Signaling in Macrophages
por: Chae, Byeong Jun, et al.
Publicado: (2023)

RNA Profiles of Tear Fluid Extracellular Vesicles in Patients with Dry Eye-Related Symptoms
por: Cross, Tanya, et al.
Publicado: (2023)

Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases
por: Liu, Baolong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ap31pcaimmsbrotjfoeb6qiaep