Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line

Among patients with the rare diagnosis of pancreatic neuroendocrine tumor (P-NET), a substantial proportion suffer from the inherited cancer syndrome multiple endocrine neoplasia type 1 (MEN1), which is caused by germline mutations of the MEN1 suppressor gene. Somatic mutations and loss of the MEN1...

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Detalles Bibliográficos
Autores principales: Monazzam, Azita, Li, Su-Chen, Wargelius, Hanna, Razmara, Masoud, Bajic, Duska, Mi, Jia, Bergquist, Jonas, Crona, Joakim, Skogseid, Britt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471701/
https://www.ncbi.nlm.nih.gov/pubmed/32884006
http://dx.doi.org/10.1038/s41598-020-71516-7

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