Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler

The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer s...

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Autores principales: Su, Hang, Yang, Chonghui, Jin, Chenrong, Zhang, He, Yin, Chengcheng, Yang, Yang, Chen, Haoyuan, Jing, Li, Qi, Bin, Zhao, Daqing, Bai, Xueyuan, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471787/
https://www.ncbi.nlm.nih.gov/pubmed/32908856
http://dx.doi.org/10.1155/2020/7192896
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author Su, Hang
Yang, Chonghui
Jin, Chenrong
Zhang, He
Yin, Chengcheng
Yang, Yang
Chen, Haoyuan
Jing, Li
Qi, Bin
Zhao, Daqing
Bai, Xueyuan
Liu, Li
author_facet Su, Hang
Yang, Chonghui
Jin, Chenrong
Zhang, He
Yin, Chengcheng
Yang, Yang
Chen, Haoyuan
Jing, Li
Qi, Bin
Zhao, Daqing
Bai, Xueyuan
Liu, Li
author_sort Su, Hang
collection PubMed
description The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not. Our previous comparative study between sika deer and red deer suggests that the metabolic pathways between them are profoundly different based on protein level. Therefore, the metabolomic technology is used to identify and quantify the metabolites in antler samples, providing interesting insights into differential metabolite profile of antlers between sika deer and red deer. The distinct metabolic characteristics of sika deer compared to red deer provide an opportunity to explain why the red deer antler with a larger size. The enrichment analysis of differential metabolites showed that three pathways including glycine and serine metabolism, methionine metabolism, and pterine biosynthesis had a significant difference between two antler groups.
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spelling pubmed-74717872020-09-08 Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler Su, Hang Yang, Chonghui Jin, Chenrong Zhang, He Yin, Chengcheng Yang, Yang Chen, Haoyuan Jing, Li Qi, Bin Zhao, Daqing Bai, Xueyuan Liu, Li Int J Genomics Research Article The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not. Our previous comparative study between sika deer and red deer suggests that the metabolic pathways between them are profoundly different based on protein level. Therefore, the metabolomic technology is used to identify and quantify the metabolites in antler samples, providing interesting insights into differential metabolite profile of antlers between sika deer and red deer. The distinct metabolic characteristics of sika deer compared to red deer provide an opportunity to explain why the red deer antler with a larger size. The enrichment analysis of differential metabolites showed that three pathways including glycine and serine metabolism, methionine metabolism, and pterine biosynthesis had a significant difference between two antler groups. Hindawi 2020-08-25 /pmc/articles/PMC7471787/ /pubmed/32908856 http://dx.doi.org/10.1155/2020/7192896 Text en Copyright © 2020 Hang Su et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Su, Hang
Yang, Chonghui
Jin, Chenrong
Zhang, He
Yin, Chengcheng
Yang, Yang
Chen, Haoyuan
Jing, Li
Qi, Bin
Zhao, Daqing
Bai, Xueyuan
Liu, Li
Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
title Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
title_full Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
title_fullStr Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
title_full_unstemmed Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
title_short Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler
title_sort comparative metabolomics study revealed difference in central carbon metabolism between sika deer and red deer antler
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471787/
https://www.ncbi.nlm.nih.gov/pubmed/32908856
http://dx.doi.org/10.1155/2020/7192896
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