A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice

Enterovirus 71 (EV71) is the major causative pathogen of human hand, foot, and mouth disease (hHFMD) and has evolved to use various cellular receptors for infection. However, the relationship between receptor preference and EV71 virulence has not been fully revealed. By using reverse genetics, we id...

Descripción completa

Detalles Bibliográficos
Autores principales: Ke, Xianliang, Zhang, Yuan, Liu, Yan, Miao, Yuanjiu, Zheng, Caishang, Luo, Dan, Sun, Jianhong, Hu, Qinxue, Xu, Yi, Wang, Hanzhong, Zheng, Zhenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472116/
https://www.ncbi.nlm.nih.gov/pubmed/32823486
http://dx.doi.org/10.3390/v12080883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472116/
https://www.ncbi.nlm.nih.gov/pubmed/32823486
http://dx.doi.org/10.3390/v12080883

Ejemplares similares