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Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients

COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here,...

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Detalles Bibliográficos
Autores principales: Jouan, Youenn, Guillon, Antoine, Gonzalez, Loïc, Perez, Yonatan, Boisseau, Chloé, Ehrmann, Stephan, Ferreira, Marion, Daix, Thomas, Jeannet, Robin, François, Bruno, Dequin, Pierre-François, Si-Tahar, Mustapha, Baranek, Thomas, Paget, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472174/
https://www.ncbi.nlm.nih.gov/pubmed/32886755
http://dx.doi.org/10.1084/jem.20200872
Descripción
Sumario:COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS.