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Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients

COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here,...

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Autores principales: Jouan, Youenn, Guillon, Antoine, Gonzalez, Loïc, Perez, Yonatan, Boisseau, Chloé, Ehrmann, Stephan, Ferreira, Marion, Daix, Thomas, Jeannet, Robin, François, Bruno, Dequin, Pierre-François, Si-Tahar, Mustapha, Baranek, Thomas, Paget, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472174/
https://www.ncbi.nlm.nih.gov/pubmed/32886755
http://dx.doi.org/10.1084/jem.20200872
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author Jouan, Youenn
Guillon, Antoine
Gonzalez, Loïc
Perez, Yonatan
Boisseau, Chloé
Ehrmann, Stephan
Ferreira, Marion
Daix, Thomas
Jeannet, Robin
François, Bruno
Dequin, Pierre-François
Si-Tahar, Mustapha
Baranek, Thomas
Paget, Christophe
author_facet Jouan, Youenn
Guillon, Antoine
Gonzalez, Loïc
Perez, Yonatan
Boisseau, Chloé
Ehrmann, Stephan
Ferreira, Marion
Daix, Thomas
Jeannet, Robin
François, Bruno
Dequin, Pierre-François
Si-Tahar, Mustapha
Baranek, Thomas
Paget, Christophe
author_sort Jouan, Youenn
collection PubMed
description COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS.
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spelling pubmed-74721742020-09-28 Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients Jouan, Youenn Guillon, Antoine Gonzalez, Loïc Perez, Yonatan Boisseau, Chloé Ehrmann, Stephan Ferreira, Marion Daix, Thomas Jeannet, Robin François, Bruno Dequin, Pierre-François Si-Tahar, Mustapha Baranek, Thomas Paget, Christophe J Exp Med Brief Definitive Report COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS. Rockefeller University Press 2020-09-04 /pmc/articles/PMC7472174/ /pubmed/32886755 http://dx.doi.org/10.1084/jem.20200872 Text en © 2020 Jouan et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Jouan, Youenn
Guillon, Antoine
Gonzalez, Loïc
Perez, Yonatan
Boisseau, Chloé
Ehrmann, Stephan
Ferreira, Marion
Daix, Thomas
Jeannet, Robin
François, Bruno
Dequin, Pierre-François
Si-Tahar, Mustapha
Baranek, Thomas
Paget, Christophe
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
title Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
title_full Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
title_fullStr Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
title_full_unstemmed Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
title_short Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
title_sort phenotypical and functional alteration of unconventional t cells in severe covid-19 patients
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472174/
https://www.ncbi.nlm.nih.gov/pubmed/32886755
http://dx.doi.org/10.1084/jem.20200872
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