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Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here,...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472174/ https://www.ncbi.nlm.nih.gov/pubmed/32886755 http://dx.doi.org/10.1084/jem.20200872 |
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author | Jouan, Youenn Guillon, Antoine Gonzalez, Loïc Perez, Yonatan Boisseau, Chloé Ehrmann, Stephan Ferreira, Marion Daix, Thomas Jeannet, Robin François, Bruno Dequin, Pierre-François Si-Tahar, Mustapha Baranek, Thomas Paget, Christophe |
author_facet | Jouan, Youenn Guillon, Antoine Gonzalez, Loïc Perez, Yonatan Boisseau, Chloé Ehrmann, Stephan Ferreira, Marion Daix, Thomas Jeannet, Robin François, Bruno Dequin, Pierre-François Si-Tahar, Mustapha Baranek, Thomas Paget, Christophe |
author_sort | Jouan, Youenn |
collection | PubMed |
description | COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS. |
format | Online Article Text |
id | pubmed-7472174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74721742020-09-28 Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients Jouan, Youenn Guillon, Antoine Gonzalez, Loïc Perez, Yonatan Boisseau, Chloé Ehrmann, Stephan Ferreira, Marion Daix, Thomas Jeannet, Robin François, Bruno Dequin, Pierre-François Si-Tahar, Mustapha Baranek, Thomas Paget, Christophe J Exp Med Brief Definitive Report COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS. Rockefeller University Press 2020-09-04 /pmc/articles/PMC7472174/ /pubmed/32886755 http://dx.doi.org/10.1084/jem.20200872 Text en © 2020 Jouan et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Jouan, Youenn Guillon, Antoine Gonzalez, Loïc Perez, Yonatan Boisseau, Chloé Ehrmann, Stephan Ferreira, Marion Daix, Thomas Jeannet, Robin François, Bruno Dequin, Pierre-François Si-Tahar, Mustapha Baranek, Thomas Paget, Christophe Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |
title | Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |
title_full | Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |
title_fullStr | Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |
title_full_unstemmed | Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |
title_short | Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients |
title_sort | phenotypical and functional alteration of unconventional t cells in severe covid-19 patients |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472174/ https://www.ncbi.nlm.nih.gov/pubmed/32886755 http://dx.doi.org/10.1084/jem.20200872 |
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