Cargando…

OMICs Approaches in Diarrhetic Shellfish Toxins Research

Diarrhetic shellfish toxins (DSTs) are among the most prevalent marine toxins in Europe’s and in other temperate coastal regions. These toxins are produced by several dinoflagellate species; however, the contamination of the marine trophic chain is often attributed to species of the genus Dinophysis...

Descripción completa

Detalles Bibliográficos
Autores principales: Campos, Alexandre, Freitas, Marisa, de Almeida, André M., Martins, José Carlos, Domínguez-Pérez, Dany, Osório, Hugo, Vasconcelos, Vitor, Reis Costa, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472309/
https://www.ncbi.nlm.nih.gov/pubmed/32752012
http://dx.doi.org/10.3390/toxins12080493
_version_ 1783578959196192768
author Campos, Alexandre
Freitas, Marisa
de Almeida, André M.
Martins, José Carlos
Domínguez-Pérez, Dany
Osório, Hugo
Vasconcelos, Vitor
Reis Costa, Pedro
author_facet Campos, Alexandre
Freitas, Marisa
de Almeida, André M.
Martins, José Carlos
Domínguez-Pérez, Dany
Osório, Hugo
Vasconcelos, Vitor
Reis Costa, Pedro
author_sort Campos, Alexandre
collection PubMed
description Diarrhetic shellfish toxins (DSTs) are among the most prevalent marine toxins in Europe’s and in other temperate coastal regions. These toxins are produced by several dinoflagellate species; however, the contamination of the marine trophic chain is often attributed to species of the genus Dinophysis. This group of toxins, constituted by okadaic acid (OA) and analogous molecules (dinophysistoxins, DTXs), are highly harmful to humans, causing severe poisoning symptoms caused by the ingestion of contaminated seafood. Knowledge on the mode of action and toxicology of OA and the chemical characterization and accumulation of DSTs in seafood species (bivalves, gastropods and crustaceans) has significantly contributed to understand the impacts of these toxins in humans. Considerable information is however missing, particularly at the molecular and metabolic levels involving toxin uptake, distribution, compartmentalization and biotransformation and the interaction of DSTs with aquatic organisms. Recent contributions to the knowledge of DSTs arise from transcriptomics and proteomics research. Indeed, OMICs constitute a research field dedicated to the systematic analysis on the organisms’ metabolisms. The methodologies used in OMICs are also highly effective to identify critical metabolic pathways affecting the physiology of the organisms. In this review, we analyze the main contributions provided so far by OMICs to DSTs research and discuss the prospects of OMICs with regard to the DSTs toxicology and the significance of these toxins to public health, food safety and aquaculture.
format Online
Article
Text
id pubmed-7472309
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74723092020-09-04 OMICs Approaches in Diarrhetic Shellfish Toxins Research Campos, Alexandre Freitas, Marisa de Almeida, André M. Martins, José Carlos Domínguez-Pérez, Dany Osório, Hugo Vasconcelos, Vitor Reis Costa, Pedro Toxins (Basel) Review Diarrhetic shellfish toxins (DSTs) are among the most prevalent marine toxins in Europe’s and in other temperate coastal regions. These toxins are produced by several dinoflagellate species; however, the contamination of the marine trophic chain is often attributed to species of the genus Dinophysis. This group of toxins, constituted by okadaic acid (OA) and analogous molecules (dinophysistoxins, DTXs), are highly harmful to humans, causing severe poisoning symptoms caused by the ingestion of contaminated seafood. Knowledge on the mode of action and toxicology of OA and the chemical characterization and accumulation of DSTs in seafood species (bivalves, gastropods and crustaceans) has significantly contributed to understand the impacts of these toxins in humans. Considerable information is however missing, particularly at the molecular and metabolic levels involving toxin uptake, distribution, compartmentalization and biotransformation and the interaction of DSTs with aquatic organisms. Recent contributions to the knowledge of DSTs arise from transcriptomics and proteomics research. Indeed, OMICs constitute a research field dedicated to the systematic analysis on the organisms’ metabolisms. The methodologies used in OMICs are also highly effective to identify critical metabolic pathways affecting the physiology of the organisms. In this review, we analyze the main contributions provided so far by OMICs to DSTs research and discuss the prospects of OMICs with regard to the DSTs toxicology and the significance of these toxins to public health, food safety and aquaculture. MDPI 2020-07-31 /pmc/articles/PMC7472309/ /pubmed/32752012 http://dx.doi.org/10.3390/toxins12080493 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Campos, Alexandre
Freitas, Marisa
de Almeida, André M.
Martins, José Carlos
Domínguez-Pérez, Dany
Osório, Hugo
Vasconcelos, Vitor
Reis Costa, Pedro
OMICs Approaches in Diarrhetic Shellfish Toxins Research
title OMICs Approaches in Diarrhetic Shellfish Toxins Research
title_full OMICs Approaches in Diarrhetic Shellfish Toxins Research
title_fullStr OMICs Approaches in Diarrhetic Shellfish Toxins Research
title_full_unstemmed OMICs Approaches in Diarrhetic Shellfish Toxins Research
title_short OMICs Approaches in Diarrhetic Shellfish Toxins Research
title_sort omics approaches in diarrhetic shellfish toxins research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472309/
https://www.ncbi.nlm.nih.gov/pubmed/32752012
http://dx.doi.org/10.3390/toxins12080493
work_keys_str_mv AT camposalexandre omicsapproachesindiarrheticshellfishtoxinsresearch
AT freitasmarisa omicsapproachesindiarrheticshellfishtoxinsresearch
AT dealmeidaandrem omicsapproachesindiarrheticshellfishtoxinsresearch
AT martinsjosecarlos omicsapproachesindiarrheticshellfishtoxinsresearch
AT dominguezperezdany omicsapproachesindiarrheticshellfishtoxinsresearch
AT osoriohugo omicsapproachesindiarrheticshellfishtoxinsresearch
AT vasconcelosvitor omicsapproachesindiarrheticshellfishtoxinsresearch
AT reiscostapedro omicsapproachesindiarrheticshellfishtoxinsresearch