Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)

Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of morbidity and mortality, weight loss, and low mil...

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Autores principales: Marcacci, Maurilia, Khalafalla, Abdelmalik I., Al Hammadi, Zulaikha M., Monaco, Federica, Cammà, Cesare, Yusof, Mohammed F., Al Yammahi, Saeed M., Mangone, Iolanda, Valleriani, Fabrizia, Alhosani, Mohamed A., Decaro, Nicola, Lorusso, Alessio, Almuhairi, Salama S., Savini, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472314/
https://www.ncbi.nlm.nih.gov/pubmed/32717784
http://dx.doi.org/10.3390/v12080786
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author Marcacci, Maurilia
Khalafalla, Abdelmalik I.
Al Hammadi, Zulaikha M.
Monaco, Federica
Cammà, Cesare
Yusof, Mohammed F.
Al Yammahi, Saeed M.
Mangone, Iolanda
Valleriani, Fabrizia
Alhosani, Mohamed A.
Decaro, Nicola
Lorusso, Alessio
Almuhairi, Salama S.
Savini, Giovanni
author_facet Marcacci, Maurilia
Khalafalla, Abdelmalik I.
Al Hammadi, Zulaikha M.
Monaco, Federica
Cammà, Cesare
Yusof, Mohammed F.
Al Yammahi, Saeed M.
Mangone, Iolanda
Valleriani, Fabrizia
Alhosani, Mohamed A.
Decaro, Nicola
Lorusso, Alessio
Almuhairi, Salama S.
Savini, Giovanni
author_sort Marcacci, Maurilia
collection PubMed
description Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of morbidity and mortality, weight loss, and low milk yield. Prevention of camelpox is performed by vaccination. In this study, we investigated the composition of a CMLV-based, live-attenuated commercial vaccine using next-generation sequencing (NGS) technology. The results of this analysis revealed genomic sequences of Modified Vaccinia virus Ankara (MVA).
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spelling pubmed-74723142020-09-04 Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA) Marcacci, Maurilia Khalafalla, Abdelmalik I. Al Hammadi, Zulaikha M. Monaco, Federica Cammà, Cesare Yusof, Mohammed F. Al Yammahi, Saeed M. Mangone, Iolanda Valleriani, Fabrizia Alhosani, Mohamed A. Decaro, Nicola Lorusso, Alessio Almuhairi, Salama S. Savini, Giovanni Viruses Brief Report Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of morbidity and mortality, weight loss, and low milk yield. Prevention of camelpox is performed by vaccination. In this study, we investigated the composition of a CMLV-based, live-attenuated commercial vaccine using next-generation sequencing (NGS) technology. The results of this analysis revealed genomic sequences of Modified Vaccinia virus Ankara (MVA). MDPI 2020-07-23 /pmc/articles/PMC7472314/ /pubmed/32717784 http://dx.doi.org/10.3390/v12080786 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Marcacci, Maurilia
Khalafalla, Abdelmalik I.
Al Hammadi, Zulaikha M.
Monaco, Federica
Cammà, Cesare
Yusof, Mohammed F.
Al Yammahi, Saeed M.
Mangone, Iolanda
Valleriani, Fabrizia
Alhosani, Mohamed A.
Decaro, Nicola
Lorusso, Alessio
Almuhairi, Salama S.
Savini, Giovanni
Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)
title Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)
title_full Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)
title_fullStr Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)
title_full_unstemmed Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)
title_short Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Vaccinia virus Ankara (MVA)
title_sort genome sequencing of a camelpox vaccine reveals close similarity to modified vaccinia virus ankara (mva)
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472314/
https://www.ncbi.nlm.nih.gov/pubmed/32717784
http://dx.doi.org/10.3390/v12080786
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