Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a robust environmental risk factor for neurodegenerative diseases including Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, blood–brain barrier (BBB) dysfunction is also a hallmark e...

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Autores principales: Wu, Yingxi, Wu, Haijian, Guo, Xinying, Pluimer, Brock, Zhao, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472692/
https://www.ncbi.nlm.nih.gov/pubmed/32973558
http://dx.doi.org/10.3389/fphys.2020.01030
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author Wu, Yingxi
Wu, Haijian
Guo, Xinying
Pluimer, Brock
Zhao, Zhen
author_facet Wu, Yingxi
Wu, Haijian
Guo, Xinying
Pluimer, Brock
Zhao, Zhen
author_sort Wu, Yingxi
collection PubMed
description Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a robust environmental risk factor for neurodegenerative diseases including Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, blood–brain barrier (BBB) dysfunction is also a hallmark event of the pathological cascades after mTBI. However, the vascular link between BBB impairment caused by mTBI and subsequent neurodegeneration remains undefined. In this review, we focus on the preclinical evidence from murine models of BBB dysfunction in mTBI and provide potential mechanistic links between BBB disruption and the development of neurodegenerative diseases.
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spelling pubmed-74726922020-09-23 Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models Wu, Yingxi Wu, Haijian Guo, Xinying Pluimer, Brock Zhao, Zhen Front Physiol Physiology Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a robust environmental risk factor for neurodegenerative diseases including Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, blood–brain barrier (BBB) dysfunction is also a hallmark event of the pathological cascades after mTBI. However, the vascular link between BBB impairment caused by mTBI and subsequent neurodegeneration remains undefined. In this review, we focus on the preclinical evidence from murine models of BBB dysfunction in mTBI and provide potential mechanistic links between BBB disruption and the development of neurodegenerative diseases. Frontiers Media S.A. 2020-08-21 /pmc/articles/PMC7472692/ /pubmed/32973558 http://dx.doi.org/10.3389/fphys.2020.01030 Text en Copyright © 2020 Wu, Wu, Guo, Pluimer and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wu, Yingxi
Wu, Haijian
Guo, Xinying
Pluimer, Brock
Zhao, Zhen
Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models
title Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models
title_full Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models
title_fullStr Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models
title_full_unstemmed Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models
title_short Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models
title_sort blood–brain barrier dysfunction in mild traumatic brain injury: evidence from preclinical murine models
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472692/
https://www.ncbi.nlm.nih.gov/pubmed/32973558
http://dx.doi.org/10.3389/fphys.2020.01030
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