High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration

[Image: see text] A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By ap...

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Autores principales: Guo, Ang, Burleigh, Robert J., Smith, Natasha, Brouard, Mark, Burt, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472747/
https://www.ncbi.nlm.nih.gov/pubmed/32811151
http://dx.doi.org/10.1021/jasms.0c00167
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author Guo, Ang
Burleigh, Robert J.
Smith, Natasha
Brouard, Mark
Burt, Michael
author_facet Guo, Ang
Burleigh, Robert J.
Smith, Natasha
Brouard, Mark
Burt, Michael
author_sort Guo, Ang
collection PubMed
description [Image: see text] A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly rising potential to the ion extraction electrode, sequential m/z ratios were subjected to a changing electric field, allowing their foci to coincide at the detector. Using this approach, at least 75% of the maximum mass resolution was obtained over a 300–600 Da range when the ion microscope was focused around 450 Da, representing more than a 10-fold increase over the conventional single-field PEDA method.
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spelling pubmed-74727472020-09-08 High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration Guo, Ang Burleigh, Robert J. Smith, Natasha Brouard, Mark Burt, Michael J Am Soc Mass Spectrom [Image: see text] A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly rising potential to the ion extraction electrode, sequential m/z ratios were subjected to a changing electric field, allowing their foci to coincide at the detector. Using this approach, at least 75% of the maximum mass resolution was obtained over a 300–600 Da range when the ion microscope was focused around 450 Da, representing more than a 10-fold increase over the conventional single-field PEDA method. American Chemical Society 2020-07-31 2020-09-02 /pmc/articles/PMC7472747/ /pubmed/32811151 http://dx.doi.org/10.1021/jasms.0c00167 Text en Published by the American Chemical Society. All rights reserved. This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Guo, Ang
Burleigh, Robert J.
Smith, Natasha
Brouard, Mark
Burt, Michael
High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration
title High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration
title_full High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration
title_fullStr High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration
title_full_unstemmed High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration
title_short High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration
title_sort high-resolution ion microscope imaging over wide mass ranges using electrodynamic postextraction differential acceleration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472747/
https://www.ncbi.nlm.nih.gov/pubmed/32811151
http://dx.doi.org/10.1021/jasms.0c00167
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