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Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection

Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infectio...

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Detalles Bibliográficos
Autores principales: Ren, Zhihua, Zhang, Xiaojie, Ding, Ting, Zhong, Zhijun, Hu, Hui, Xu, Zhiwen, Deng, Junliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472841/
https://www.ncbi.nlm.nih.gov/pubmed/32973718
http://dx.doi.org/10.3389/fmicb.2020.01992
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author Ren, Zhihua
Zhang, Xiaojie
Ding, Ting
Zhong, Zhijun
Hu, Hui
Xu, Zhiwen
Deng, Junliang
author_facet Ren, Zhihua
Zhang, Xiaojie
Ding, Ting
Zhong, Zhijun
Hu, Hui
Xu, Zhiwen
Deng, Junliang
author_sort Ren, Zhihua
collection PubMed
description Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infection, the dynamic balance of the host cell mitochondria is disturbed, affecting the processes of energy generation, metabolism, and innate immunity. This creates an intracellular environment that is conducive to viral proliferation and begins the process of its own infection and causes further damage to the body. Herein, we discuss the mechanism of the virus-induced mitochondrial dynamics imbalance and its subsequent effects on the body, which will help to improve our understanding of the relationship between mitochondrial dynamics and viral infection and its importance.
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spelling pubmed-74728412020-09-23 Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection Ren, Zhihua Zhang, Xiaojie Ding, Ting Zhong, Zhijun Hu, Hui Xu, Zhiwen Deng, Junliang Front Microbiol Microbiology Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infection, the dynamic balance of the host cell mitochondria is disturbed, affecting the processes of energy generation, metabolism, and innate immunity. This creates an intracellular environment that is conducive to viral proliferation and begins the process of its own infection and causes further damage to the body. Herein, we discuss the mechanism of the virus-induced mitochondrial dynamics imbalance and its subsequent effects on the body, which will help to improve our understanding of the relationship between mitochondrial dynamics and viral infection and its importance. Frontiers Media S.A. 2020-08-21 /pmc/articles/PMC7472841/ /pubmed/32973718 http://dx.doi.org/10.3389/fmicb.2020.01992 Text en Copyright © 2020 Ren, Zhang, Ding, Zhong, Hu, Xu and Deng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ren, Zhihua
Zhang, Xiaojie
Ding, Ting
Zhong, Zhijun
Hu, Hui
Xu, Zhiwen
Deng, Junliang
Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
title Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
title_full Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
title_fullStr Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
title_full_unstemmed Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
title_short Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
title_sort mitochondrial dynamics imbalance: a strategy for promoting viral infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472841/
https://www.ncbi.nlm.nih.gov/pubmed/32973718
http://dx.doi.org/10.3389/fmicb.2020.01992
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