Cargando…
Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infectio...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472841/ https://www.ncbi.nlm.nih.gov/pubmed/32973718 http://dx.doi.org/10.3389/fmicb.2020.01992 |
_version_ | 1783579065919209472 |
---|---|
author | Ren, Zhihua Zhang, Xiaojie Ding, Ting Zhong, Zhijun Hu, Hui Xu, Zhiwen Deng, Junliang |
author_facet | Ren, Zhihua Zhang, Xiaojie Ding, Ting Zhong, Zhijun Hu, Hui Xu, Zhiwen Deng, Junliang |
author_sort | Ren, Zhihua |
collection | PubMed |
description | Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infection, the dynamic balance of the host cell mitochondria is disturbed, affecting the processes of energy generation, metabolism, and innate immunity. This creates an intracellular environment that is conducive to viral proliferation and begins the process of its own infection and causes further damage to the body. Herein, we discuss the mechanism of the virus-induced mitochondrial dynamics imbalance and its subsequent effects on the body, which will help to improve our understanding of the relationship between mitochondrial dynamics and viral infection and its importance. |
format | Online Article Text |
id | pubmed-7472841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74728412020-09-23 Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection Ren, Zhihua Zhang, Xiaojie Ding, Ting Zhong, Zhijun Hu, Hui Xu, Zhiwen Deng, Junliang Front Microbiol Microbiology Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusion via kinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infection, the dynamic balance of the host cell mitochondria is disturbed, affecting the processes of energy generation, metabolism, and innate immunity. This creates an intracellular environment that is conducive to viral proliferation and begins the process of its own infection and causes further damage to the body. Herein, we discuss the mechanism of the virus-induced mitochondrial dynamics imbalance and its subsequent effects on the body, which will help to improve our understanding of the relationship between mitochondrial dynamics and viral infection and its importance. Frontiers Media S.A. 2020-08-21 /pmc/articles/PMC7472841/ /pubmed/32973718 http://dx.doi.org/10.3389/fmicb.2020.01992 Text en Copyright © 2020 Ren, Zhang, Ding, Zhong, Hu, Xu and Deng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Ren, Zhihua Zhang, Xiaojie Ding, Ting Zhong, Zhijun Hu, Hui Xu, Zhiwen Deng, Junliang Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection |
title | Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection |
title_full | Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection |
title_fullStr | Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection |
title_full_unstemmed | Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection |
title_short | Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection |
title_sort | mitochondrial dynamics imbalance: a strategy for promoting viral infection |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472841/ https://www.ncbi.nlm.nih.gov/pubmed/32973718 http://dx.doi.org/10.3389/fmicb.2020.01992 |
work_keys_str_mv | AT renzhihua mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection AT zhangxiaojie mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection AT dingting mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection AT zhongzhijun mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection AT huhui mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection AT xuzhiwen mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection AT dengjunliang mitochondrialdynamicsimbalanceastrategyforpromotingviralinfection |