Cargando…

Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the mechanism by which T cells develop this phenotype in solid tumors is needed. Here, hypoxia, a feature of the tumor microenvironment, causes T cell exhaustion (T(Exh)) by inducing a mitochondrial defect. Upon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yi-Na, Yang, Jie-Feng, Huang, Dai-Jia, Ni, Huan-He, Zhang, Chuan-Xia, Zhang, Lin, He, Jia, Gu, Jia-Mei, Chen, Hong-Xia, Mai, Hai-Qiang, Chen, Qiu-Yan, Zhang, Xiao-Shi, Gao, Song, Li, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472844/ https://www.ncbi.nlm.nih.gov/pubmed/32973789 http://dx.doi.org/10.3389/fimmu.2020.01906

Ejemplares similares

NK cell exhaustion in the tumor microenvironment
por: Jia, Hao, et al.
Publicado: (2023)

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation
por: Zhang, Chuan-xia, et al.
Publicado: (2020)

Correction to: Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation
por: Zhang, Chuan-xia, et al.
Publicado: (2022)

Role of hypoxia in the tumor microenvironment and targeted therapy
por: Chen, Gaoqi, et al.
Publicado: (2022)

Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma
por: Zhang, Wenshuo, et al.
Publicado: (2022)

Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery
por: Dai, Chen-Xin, et al.
Publicado: (2009)

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
por: McRitchie, Bayley R., et al.
Publicado: (2022)

A supramolecular nanoplatform for imaging-guided phototherapies via hypoxia tumour microenvironment remodeling
por: Zhou, Weijie, et al.
Publicado: (2023)

T-cell exhaustion in the tumor microenvironment
por: Jiang, Y, et al.
Publicado: (2015)

Hypoxia promotes pulmonary vascular remodeling via HIF-1α to regulate mitochondrial dynamics
por: Chen, Xi, et al.
Publicado: (2019)

MAP4 Mechanism that Stabilizes Mitochondrial Permeability Transition in Hypoxia: Microtubule Enhancement and DYNLT1 Interaction with VDAC1
por: Fang, Ya-dong, et al.
Publicado: (2011)

CAPN8 involves with exhausted, inflamed, and desert immune microenvironment to influence the metastasis of thyroid cancer
por: Zhong, Xiang, et al.
Publicado: (2022)

Molecular Mechanism Underlying Hypoxic Preconditioning-Promoted Mitochondrial Translocation of DJ-1 in Hypoxia/Reoxygenation H9c2 Cells
por: Deng, Yi-Zhang, et al.
Publicado: (2019)

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
por: Scharping, Nicole E., et al.
Publicado: (2021)

Experimental study on diesel engine exhaust gas recirculation performance and optimum exhaust gas recirculation rate determination method
por: Zu, Xiang-huan, et al.
Publicado: (2019)

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
por: Jiang, Weiqin, et al.
Publicado: (2021)

Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells
por: Huang, Yue, et al.
Publicado: (2022)

m6A-Regulator Expression Signatures Identify a Subset of Follicular Lymphoma Harboring an Exhausted Tumor Microenvironment
por: Zhang, Tingting, et al.
Publicado: (2022)

Tumor microenvironment: becoming sick of Myc
por: Whitfield, Jonathan R., et al.
Publicado: (2011)

Anti-carbonic anhydrase II antibody reflects urinary acidification defect especially in proximal renal tubules in patients with primary Sjögren syndrome
por: Jin, Yue-Bo, et al.
Publicado: (2023)

Tumor-infiltrating CD36(+)CD8(+)T cells determine exhausted tumor microenvironment and correlate with inferior response to chemotherapy in non-small cell lung cancer
por: Ao, Yong-Qiang, et al.
Publicado: (2023)

Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment
por: Zhang, Hongxia, et al.
Publicado: (2023)

Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma
por: Liu, Fangming, et al.
Publicado: (2020)

The complete mitochondrial genome of Annamanum lunulatum (Coleoptera: Lamiinae) and its phylogeny
por: Dai, Xin-Yi, et al.
Publicado: (2020)

Radiosensitizing effects of c-myc gene knockdown-induced G2/M phase arrest by intrinsic stimuli via the mitochondrial signaling pathway
por: Fan, Yunpeng, et al.
Publicado: (2020)

Cell Cycle Re-Entry and Mitochondrial Defects in Myc-Mediated Hypertrophic Cardiomyopathy and Heart Failure
por: Lee, Hyoung-gon, et al.
Publicado: (2009)

A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment
por: Liu, Yu-Tzu, et al.
Publicado: (2018)

T-Cell Exhaustion Status Under High and Low Levels of Hypoxia-Inducible Factor 1α Expression in Glioma
por: Liu, Shuai, et al.
Publicado: (2021)

TCRP1 transcriptionally regulated by c-Myc confers cancer chemoresistance in tongue and lung cancer
por: Jia, Xiaoting, et al.
Publicado: (2017)

Screening and Validation of the Hypoxia-Related Signature of Evaluating Tumor Immune Microenvironment and Predicting Prognosis in Gastric Cancer
por: Pei, Jun-Peng, et al.
Publicado: (2021)

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma
por: Cai, Ting-Ting, et al.
Publicado: (2017)

Visualization of ligand-induced c-MYC duplex–quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells
por: Yuan, Jia-Hao, et al.
Publicado: (2022)

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules
por: Chen, Yi-Fan, et al.
Publicado: (2019)

Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis
por: Zhang, Xiaoyang, et al.
Publicado: (2019)

PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology
por: Chen, Zheng, et al.
Publicado: (2021)

MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma
por: Jiang, Kuo, et al.
Publicado: (2022)

T cell exhaustion is associated with the risk of papillary thyroid carcinoma and can be a predictive and sensitive biomarker for diagnosis
por: Zhu, Chumeng, et al.
Publicado: (2021)

IBTK Haploinsufficiency Affects the Tumor Microenvironment of Myc-Driven Lymphoma in E-myc Mice
por: Vecchio, Eleonora, et al.
Publicado: (2020)

Metabonomics window into plateau hypoxia
por: Chang, Yue, et al.
Publicado: (2019)

NAD(+) exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension
por: Qiu, Yumin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3v65iv245q3u7ar571hfr9n0he