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Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the infla...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472961/ https://www.ncbi.nlm.nih.gov/pubmed/32973746 http://dx.doi.org/10.3389/fimmu.2020.01767 |
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author | Wu, Chenyun Du, Xinyue Tang, Lili Wu, Jianhua Zhao, Wei Guo, Xiaokui Liu, Dengyu Hu, Wei Helmby, Helena Chen, Guangjie Wang, Zhaojun |
author_facet | Wu, Chenyun Du, Xinyue Tang, Lili Wu, Jianhua Zhao, Wei Guo, Xiaokui Liu, Dengyu Hu, Wei Helmby, Helena Chen, Guangjie Wang, Zhaojun |
author_sort | Wu, Chenyun |
collection | PubMed |
description | Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the inflammatory granuloma response in schistosomiasis. Here, we show that SjE16.7 binds to host cells by interacting with receptors for advanced glycation end products (RAGE). This ligation leads to activation of the NF-κB signaling pathway, an increase in the generation of reactive oxygen species, and production of the pro-inflammatory cytokines IL-6 and TNF-α. Using a mouse model of colorectal cancer, we demonstrate that intraperitoneal injection of SjE16.7 promotes colorectal cancer progression along with systemic myeloid cell accumulation. Thus, our results identify a new helminth antigen contributing to tumor development in the mammalian host. |
format | Online Article Text |
id | pubmed-7472961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74729612020-09-23 Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) Wu, Chenyun Du, Xinyue Tang, Lili Wu, Jianhua Zhao, Wei Guo, Xiaokui Liu, Dengyu Hu, Wei Helmby, Helena Chen, Guangjie Wang, Zhaojun Front Immunol Immunology Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the inflammatory granuloma response in schistosomiasis. Here, we show that SjE16.7 binds to host cells by interacting with receptors for advanced glycation end products (RAGE). This ligation leads to activation of the NF-κB signaling pathway, an increase in the generation of reactive oxygen species, and production of the pro-inflammatory cytokines IL-6 and TNF-α. Using a mouse model of colorectal cancer, we demonstrate that intraperitoneal injection of SjE16.7 promotes colorectal cancer progression along with systemic myeloid cell accumulation. Thus, our results identify a new helminth antigen contributing to tumor development in the mammalian host. Frontiers Media S.A. 2020-08-21 /pmc/articles/PMC7472961/ /pubmed/32973746 http://dx.doi.org/10.3389/fimmu.2020.01767 Text en Copyright © 2020 Wu, Du, Tang, Wu, Zhao, Guo, Liu, Hu, Helmby, Chen and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Chenyun Du, Xinyue Tang, Lili Wu, Jianhua Zhao, Wei Guo, Xiaokui Liu, Dengyu Hu, Wei Helmby, Helena Chen, Guangjie Wang, Zhaojun Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) |
title | Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) |
title_full | Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) |
title_fullStr | Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) |
title_full_unstemmed | Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) |
title_short | Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) |
title_sort | schistosoma japonicum sje16.7 protein promotes tumor development via the receptor for advanced glycation end products (rage) |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472961/ https://www.ncbi.nlm.nih.gov/pubmed/32973746 http://dx.doi.org/10.3389/fimmu.2020.01767 |
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