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Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)

Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the infla...

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Autores principales: Wu, Chenyun, Du, Xinyue, Tang, Lili, Wu, Jianhua, Zhao, Wei, Guo, Xiaokui, Liu, Dengyu, Hu, Wei, Helmby, Helena, Chen, Guangjie, Wang, Zhaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472961/
https://www.ncbi.nlm.nih.gov/pubmed/32973746
http://dx.doi.org/10.3389/fimmu.2020.01767
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author Wu, Chenyun
Du, Xinyue
Tang, Lili
Wu, Jianhua
Zhao, Wei
Guo, Xiaokui
Liu, Dengyu
Hu, Wei
Helmby, Helena
Chen, Guangjie
Wang, Zhaojun
author_facet Wu, Chenyun
Du, Xinyue
Tang, Lili
Wu, Jianhua
Zhao, Wei
Guo, Xiaokui
Liu, Dengyu
Hu, Wei
Helmby, Helena
Chen, Guangjie
Wang, Zhaojun
author_sort Wu, Chenyun
collection PubMed
description Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the inflammatory granuloma response in schistosomiasis. Here, we show that SjE16.7 binds to host cells by interacting with receptors for advanced glycation end products (RAGE). This ligation leads to activation of the NF-κB signaling pathway, an increase in the generation of reactive oxygen species, and production of the pro-inflammatory cytokines IL-6 and TNF-α. Using a mouse model of colorectal cancer, we demonstrate that intraperitoneal injection of SjE16.7 promotes colorectal cancer progression along with systemic myeloid cell accumulation. Thus, our results identify a new helminth antigen contributing to tumor development in the mammalian host.
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spelling pubmed-74729612020-09-23 Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) Wu, Chenyun Du, Xinyue Tang, Lili Wu, Jianhua Zhao, Wei Guo, Xiaokui Liu, Dengyu Hu, Wei Helmby, Helena Chen, Guangjie Wang, Zhaojun Front Immunol Immunology Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the inflammatory granuloma response in schistosomiasis. Here, we show that SjE16.7 binds to host cells by interacting with receptors for advanced glycation end products (RAGE). This ligation leads to activation of the NF-κB signaling pathway, an increase in the generation of reactive oxygen species, and production of the pro-inflammatory cytokines IL-6 and TNF-α. Using a mouse model of colorectal cancer, we demonstrate that intraperitoneal injection of SjE16.7 promotes colorectal cancer progression along with systemic myeloid cell accumulation. Thus, our results identify a new helminth antigen contributing to tumor development in the mammalian host. Frontiers Media S.A. 2020-08-21 /pmc/articles/PMC7472961/ /pubmed/32973746 http://dx.doi.org/10.3389/fimmu.2020.01767 Text en Copyright © 2020 Wu, Du, Tang, Wu, Zhao, Guo, Liu, Hu, Helmby, Chen and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Chenyun
Du, Xinyue
Tang, Lili
Wu, Jianhua
Zhao, Wei
Guo, Xiaokui
Liu, Dengyu
Hu, Wei
Helmby, Helena
Chen, Guangjie
Wang, Zhaojun
Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
title Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
title_full Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
title_fullStr Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
title_full_unstemmed Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
title_short Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
title_sort schistosoma japonicum sje16.7 protein promotes tumor development via the receptor for advanced glycation end products (rage)
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472961/
https://www.ncbi.nlm.nih.gov/pubmed/32973746
http://dx.doi.org/10.3389/fimmu.2020.01767
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