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Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets

Alveolar macrophages (AMs) are highly abundant lung cells with important roles in homeostasis and immunity. Their function influences the outcome of lung infections, lung cancer, and chronic inflammatory disease. Recent findings reveal functional heterogeneity of AMs. Following lung insult, resident...

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Detalles Bibliográficos
Autores principales: Kulikauskaite, Justina, Wack, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472979/
https://www.ncbi.nlm.nih.gov/pubmed/32896485
http://dx.doi.org/10.1016/j.it.2020.08.008
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author Kulikauskaite, Justina
Wack, Andreas
author_facet Kulikauskaite, Justina
Wack, Andreas
author_sort Kulikauskaite, Justina
collection PubMed
description Alveolar macrophages (AMs) are highly abundant lung cells with important roles in homeostasis and immunity. Their function influences the outcome of lung infections, lung cancer, and chronic inflammatory disease. Recent findings reveal functional heterogeneity of AMs. Following lung insult, resident AMs can either remain unchanged, acquire new functionality, or be replaced by monocyte-derived AMs. Evidence from mouse models correlates AM function with their embryonic or monocyte origin. We hypothesize that resident AMs are terminally differentiated cells with low responsiveness and limited plasticity, while recruited, monocyte-derived AMs are initially highly immunoreactive but more plastic, able to change their function in response to environmental cues. Understanding cell-intrinsic and -extrinsic mechanisms determining AM function may provide opportunities for intervention in lung disease.
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spelling pubmed-74729792020-09-08 Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets Kulikauskaite, Justina Wack, Andreas Trends Immunol Opinion Alveolar macrophages (AMs) are highly abundant lung cells with important roles in homeostasis and immunity. Their function influences the outcome of lung infections, lung cancer, and chronic inflammatory disease. Recent findings reveal functional heterogeneity of AMs. Following lung insult, resident AMs can either remain unchanged, acquire new functionality, or be replaced by monocyte-derived AMs. Evidence from mouse models correlates AM function with their embryonic or monocyte origin. We hypothesize that resident AMs are terminally differentiated cells with low responsiveness and limited plasticity, while recruited, monocyte-derived AMs are initially highly immunoreactive but more plastic, able to change their function in response to environmental cues. Understanding cell-intrinsic and -extrinsic mechanisms determining AM function may provide opportunities for intervention in lung disease. The Authors. Published by Elsevier Ltd. 2020-10 2020-09-04 /pmc/articles/PMC7472979/ /pubmed/32896485 http://dx.doi.org/10.1016/j.it.2020.08.008 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Opinion
Kulikauskaite, Justina
Wack, Andreas
Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
title Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
title_full Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
title_fullStr Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
title_full_unstemmed Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
title_short Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
title_sort teaching old dogs new tricks? the plasticity of lung alveolar macrophage subsets
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472979/
https://www.ncbi.nlm.nih.gov/pubmed/32896485
http://dx.doi.org/10.1016/j.it.2020.08.008
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