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SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis

Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmen...

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Autores principales: Liu, Shengyuan, Huang, Feng, Ye, Qing, Li, Yangming, Chen, Jinhu, Huang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473003/
https://www.ncbi.nlm.nih.gov/pubmed/33029299
http://dx.doi.org/10.1080/19768354.2020.1784274
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author Liu, Shengyuan
Huang, Feng
Ye, Qing
Li, Yangming
Chen, Jinhu
Huang, Hong
author_facet Liu, Shengyuan
Huang, Feng
Ye, Qing
Li, Yangming
Chen, Jinhu
Huang, Hong
author_sort Liu, Shengyuan
collection PubMed
description Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmental processes. LncRNA-SPRY4-IT1 (GenBank ID AK024556) is derived from an intron of the SPRY4 gene, which was highly expressed in melanoma cells and affected the progression of multiple types of cancers. However, the mechanism of SPRY4-IT1 in CRC progression remains unclear. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients’ prognosis. We further noticed that SPRY4-IT1 regulated CRC cell growth and glycolysis, and promoting PDK1 expression. Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. We therefore thought SPRY4-IT1 could serve as a promising molecular target for the treatment of CRC.
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spelling pubmed-74730032020-10-06 SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis Liu, Shengyuan Huang, Feng Ye, Qing Li, Yangming Chen, Jinhu Huang, Hong Anim Cells Syst (Seoul) Molecular & Cellular Biology Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmental processes. LncRNA-SPRY4-IT1 (GenBank ID AK024556) is derived from an intron of the SPRY4 gene, which was highly expressed in melanoma cells and affected the progression of multiple types of cancers. However, the mechanism of SPRY4-IT1 in CRC progression remains unclear. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients’ prognosis. We further noticed that SPRY4-IT1 regulated CRC cell growth and glycolysis, and promoting PDK1 expression. Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. We therefore thought SPRY4-IT1 could serve as a promising molecular target for the treatment of CRC. Taylor & Francis 2020-06-25 /pmc/articles/PMC7473003/ /pubmed/33029299 http://dx.doi.org/10.1080/19768354.2020.1784274 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Molecular & Cellular Biology
Liu, Shengyuan
Huang, Feng
Ye, Qing
Li, Yangming
Chen, Jinhu
Huang, Hong
SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
title SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
title_full SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
title_fullStr SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
title_full_unstemmed SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
title_short SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
title_sort spry4-it1 promotes survival of colorectal cancer cells through regulating pdk1-mediated glycolysis
topic Molecular & Cellular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473003/
https://www.ncbi.nlm.nih.gov/pubmed/33029299
http://dx.doi.org/10.1080/19768354.2020.1784274
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