Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing

SARS-CoV-2 utilizes the IMPα/β1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. Ivermectin has shown antiviral activity by inhibiting the formation of the importin-α (IMPα) and IMPβ1 subunits as well as dissociating the IMPα/β1 heterodimer and has in vi...

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Detalles Bibliográficos
Autores principales: Jermain, Brian, Hanafin, Patrick O., Cao, Yanguang, Lifschitz, Adrian, Lanusse, Carlos, Rao, Gauri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. on behalf of the American Pharmacists Association. 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473010/
https://www.ncbi.nlm.nih.gov/pubmed/32891630
http://dx.doi.org/10.1016/j.xphs.2020.08.024

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