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High Potency of a Bivalent Human V(H) Domain in SARS-CoV-2 Animal Models

Novel COVID-19 therapeutics are urgently needed. We generated a phage-displayed human antibody V(H) domain library from which we identified a high-affinity V(H) binder ab8. Bivalent V(H), V(H)-Fc ab8, bound with high avidity to membrane-associated S glycoprotein and to mutants found in patients. It...

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Detalles Bibliográficos
Autores principales:	Li, Wei, Schäfer, Alexandra, Kulkarni, Swarali S., Liu, Xianglei, Martinez, David R., Chen, Chuan, Sun, Zehua, Leist, Sarah R., Drelich, Aleksandra, Zhang, Liyong, Ura, Marcin L., Berezuk, Alison, Chittori, Sagar, Leopold, Karoline, Mannar, Dhiraj, Srivastava, Shanti S., Zhu, Xing, Peterson, Eric C., Tseng, Chien-Te, Mellors, John W., Falzarano, Darryl, Subramaniam, Sriram, Baric, Ralph S., Dimitrov, Dimiter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473018/ https://www.ncbi.nlm.nih.gov/pubmed/32941803 http://dx.doi.org/10.1016/j.cell.2020.09.007

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