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Biobanking for Translational Diabetes Research in India

India is declared as the diabetic capital of the world. Clinically well-annotated blood samples will advance diabetes research for better diagnostic and treatment methods. Building a disease-specific biobank with high-quality peripheral blood mononuclear cells (PBMCs) and clinical follow-up data sys...

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Autores principales: Gangadharan, Charitha, Wills, Soniya, Vangala, Rajani Kanth, Sigamani, Alben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473039/
https://www.ncbi.nlm.nih.gov/pubmed/32908805
http://dx.doi.org/10.1089/biores.2019.0052
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author Gangadharan, Charitha
Wills, Soniya
Vangala, Rajani Kanth
Sigamani, Alben
author_facet Gangadharan, Charitha
Wills, Soniya
Vangala, Rajani Kanth
Sigamani, Alben
author_sort Gangadharan, Charitha
collection PubMed
description India is declared as the diabetic capital of the world. Clinically well-annotated blood samples will advance diabetes research for better diagnostic and treatment methods. Building a disease-specific biobank with high-quality peripheral blood mononuclear cells (PBMCs) and clinical follow-up data system will serve as a good platform for clinical research in diabetes. Processing and storage of high-quality biospecimen for translational research in diabetes demand the implementation of good clinical laboratory practices. “Certification or accreditation programs” that improve biorepository processes and frameworks are lacking in Indian context. To sustain and translate the research into clinical practice, good governance of the biobank and financial resources is required. For ethical issues related to health needs of the people and participants in the research, issues related to research process, translational research, and commercialization, data sharing should be addressed. For India to be an innovation and sustainable country Indian government is supporting translational research facilities, including biobanks. India has developed biobanks for various diseases; however, diabetes-specific research biorepository is lacking. Given the dangers of diabetic burden, India should set up a diabetes disease-specific repository learning from the global organizations and customize to the needs of Indian context. It is important to have private agencies get involved to develop biobanks and future research as there are commercial goals to translate research into practice. New technologies of specimen storing and preservation, data management, and data sharing should be adopted for developing cost-effective long-standing disease-specific population biobank in India.
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spelling pubmed-74730392020-09-08 Biobanking for Translational Diabetes Research in India Gangadharan, Charitha Wills, Soniya Vangala, Rajani Kanth Sigamani, Alben Biores Open Access Literature Review India is declared as the diabetic capital of the world. Clinically well-annotated blood samples will advance diabetes research for better diagnostic and treatment methods. Building a disease-specific biobank with high-quality peripheral blood mononuclear cells (PBMCs) and clinical follow-up data system will serve as a good platform for clinical research in diabetes. Processing and storage of high-quality biospecimen for translational research in diabetes demand the implementation of good clinical laboratory practices. “Certification or accreditation programs” that improve biorepository processes and frameworks are lacking in Indian context. To sustain and translate the research into clinical practice, good governance of the biobank and financial resources is required. For ethical issues related to health needs of the people and participants in the research, issues related to research process, translational research, and commercialization, data sharing should be addressed. For India to be an innovation and sustainable country Indian government is supporting translational research facilities, including biobanks. India has developed biobanks for various diseases; however, diabetes-specific research biorepository is lacking. Given the dangers of diabetic burden, India should set up a diabetes disease-specific repository learning from the global organizations and customize to the needs of Indian context. It is important to have private agencies get involved to develop biobanks and future research as there are commercial goals to translate research into practice. New technologies of specimen storing and preservation, data management, and data sharing should be adopted for developing cost-effective long-standing disease-specific population biobank in India. Mary Ann Liebert, Inc., publishers 2020-08-19 /pmc/articles/PMC7473039/ /pubmed/32908805 http://dx.doi.org/10.1089/biores.2019.0052 Text en © Charitha Gangadharan et al., 2020; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Literature Review
Gangadharan, Charitha
Wills, Soniya
Vangala, Rajani Kanth
Sigamani, Alben
Biobanking for Translational Diabetes Research in India
title Biobanking for Translational Diabetes Research in India
title_full Biobanking for Translational Diabetes Research in India
title_fullStr Biobanking for Translational Diabetes Research in India
title_full_unstemmed Biobanking for Translational Diabetes Research in India
title_short Biobanking for Translational Diabetes Research in India
title_sort biobanking for translational diabetes research in india
topic Literature Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473039/
https://www.ncbi.nlm.nih.gov/pubmed/32908805
http://dx.doi.org/10.1089/biores.2019.0052
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