ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms

Defective cholesterol efflux pathways in mice promote the expansion of hematopoietic stem and progenitor cells and a bias toward the myeloid lineage, as observed in chronic myelomonocytic leukemia (CMML). Here, we identify 5 somatic missense mutations in ABCA1 in 26 patients with CMML. These mutatio...

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Detalles Bibliográficos
Autores principales: Viaud, Manon, Abdel-Wahab, Omar, Gall, Julie, Ivanov, Stoyan, Guinamard, Rodolphe, Sore, Sophie, Merlin, Johanna, Ayrault, Marion, Guilbaud, Emma, Jacquel, Arnaud, Auberger, Patrick, Wang, Nan, Levine, Ross L., Tall, Alan R., Yvan-Charvet, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473128/
https://www.ncbi.nlm.nih.gov/pubmed/32160545
http://dx.doi.org/10.1016/j.celrep.2020.02.056

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