Cargando…

Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness

Since the first report of the coronavirus disease (COVID-19) in late December 2019, the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now widely spread to more than 187 countries and regions. However, it is unclear whether there has been cryptic transmission bef...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Xiaoqi, Wei, Dong, Chen, Yongyan, Zhang, Donghua, Zhang, Xinxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473166/
https://www.ncbi.nlm.nih.gov/pubmed/32608335
http://dx.doi.org/10.1080/22221751.2020.1785952
_version_ 1783579131302117376
author Yu, Xiaoqi
Wei, Dong
Chen, Yongyan
Zhang, Donghua
Zhang, Xinxin
author_facet Yu, Xiaoqi
Wei, Dong
Chen, Yongyan
Zhang, Donghua
Zhang, Xinxin
author_sort Yu, Xiaoqi
collection PubMed
description Since the first report of the coronavirus disease (COVID-19) in late December 2019, the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now widely spread to more than 187 countries and regions. However, it is unclear whether there has been cryptic transmission before these early officially confirmed cases, we therefore retrospectively screened for the SARS-CoV-2 RNA in 1271 nasopharyngeal swab samples, as well as the prevalence of IgM, IgG, and total antibodies against SARS-CoV-2 in 357 matched serum samples collected from hospitalized patients with influenza-like illness between 1 December 2018 and 31 March 2020 in Shanghai Ruijin Hospital. The onset date of the earliest COVID-19 case in this study was 25 January 2020. Before this time point, the presence of SARS-CoV-2 was not observed, which limited the possibility that SARS-CoV-2 has already spread among the population before the large-scale outbreak. Additionally, among 6662 patients with influenza-like illness from 1 December 2017 to 31 March 2020, the overall number of patients positive for influenza and other respiratory viruses during the COVID-19 period decreased significantly when compared with that in the same period of the last two years, reflecting that public health interventions can effectively control the spread of common respiratory viruses.
format Online
Article
Text
id pubmed-7473166
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-74731662020-09-15 Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness Yu, Xiaoqi Wei, Dong Chen, Yongyan Zhang, Donghua Zhang, Xinxin Emerg Microbes Infect Letter Since the first report of the coronavirus disease (COVID-19) in late December 2019, the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now widely spread to more than 187 countries and regions. However, it is unclear whether there has been cryptic transmission before these early officially confirmed cases, we therefore retrospectively screened for the SARS-CoV-2 RNA in 1271 nasopharyngeal swab samples, as well as the prevalence of IgM, IgG, and total antibodies against SARS-CoV-2 in 357 matched serum samples collected from hospitalized patients with influenza-like illness between 1 December 2018 and 31 March 2020 in Shanghai Ruijin Hospital. The onset date of the earliest COVID-19 case in this study was 25 January 2020. Before this time point, the presence of SARS-CoV-2 was not observed, which limited the possibility that SARS-CoV-2 has already spread among the population before the large-scale outbreak. Additionally, among 6662 patients with influenza-like illness from 1 December 2017 to 31 March 2020, the overall number of patients positive for influenza and other respiratory viruses during the COVID-19 period decreased significantly when compared with that in the same period of the last two years, reflecting that public health interventions can effectively control the spread of common respiratory viruses. Taylor & Francis 2020-07-05 /pmc/articles/PMC7473166/ /pubmed/32608335 http://dx.doi.org/10.1080/22221751.2020.1785952 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Yu, Xiaoqi
Wei, Dong
Chen, Yongyan
Zhang, Donghua
Zhang, Xinxin
Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
title Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
title_full Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
title_fullStr Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
title_full_unstemmed Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
title_short Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
title_sort retrospective detection of sars-cov-2 in hospitalized patients with influenza-like illness
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473166/
https://www.ncbi.nlm.nih.gov/pubmed/32608335
http://dx.doi.org/10.1080/22221751.2020.1785952
work_keys_str_mv AT yuxiaoqi retrospectivedetectionofsarscov2inhospitalizedpatientswithinfluenzalikeillness
AT weidong retrospectivedetectionofsarscov2inhospitalizedpatientswithinfluenzalikeillness
AT chenyongyan retrospectivedetectionofsarscov2inhospitalizedpatientswithinfluenzalikeillness
AT zhangdonghua retrospectivedetectionofsarscov2inhospitalizedpatientswithinfluenzalikeillness
AT zhangxinxin retrospectivedetectionofsarscov2inhospitalizedpatientswithinfluenzalikeillness