The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

Replication-blocking DNA lesions are particularly toxic to proliferating cells because they can lead to chromosome mis-segregation if not repaired prior to mitosis. In this study, we report that ZGRF1 null cells accumulate chromosome aberrations following replication perturbation and show sensitivit...

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Detalles Bibliográficos
Autores principales: Brannvoll, André, Xue, Xiaoyu, Kwon, Youngho, Kompocholi, Smaragdi, Simonsen, Anne Katrine W., Viswalingam, Keerthana S., Gonzalez, Leticia, Hickson, Ian D., Oestergaard, Vibe H., Mankouri, Hocine W., Sung, Patrick, Lisby, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473174/
https://www.ncbi.nlm.nih.gov/pubmed/32640219
http://dx.doi.org/10.1016/j.celrep.2020.107849

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