Cargando…

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F, have been shown to be functionally dysregulated in certain human immune-mediated inflammatory diseases such as pso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adams, Ralph, Maroof, Asher, Baker, Terry, Lawson, Alastair D. G., Oliver, Ruth, Paveley, Ross, Rapecki, Steve, Shaw, Stevan, Vajjah, Pavan, West, Shauna, Griffiths, Meryn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473305/ https://www.ncbi.nlm.nih.gov/pubmed/32973785 http://dx.doi.org/10.3389/fimmu.2020.01894

Ejemplares similares

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation
por: Glatt, Sophie, et al.
Publicado: (2018)

First‐in‐human randomized study of bimekizumab, a humanized monoclonal antibody and selective dual inhibitor of IL‐17A and IL‐17F, in mild psoriasis
por: Glatt, Sophie, et al.
Publicado: (2017)

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells
por: Shah, Mittal, et al.
Publicado: (2020)

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling
por: Cole, Suzanne, et al.
Publicado: (2020)

Serum concentrations of IL-17A, IL-17B, IL-17E and IL-17F in patients with systemic sclerosis
por: Robak, Ewa, et al.
Publicado: (2019)

IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling
por: Goepfert, Arnaud, et al.
Publicado: (2022)

New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function
por: Saviano, Anella, et al.
Publicado: (2023)

IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis
por: Dhaouadi, Tarak, et al.
Publicado: (2018)

The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond
por: Brembilla, Nicolo Costantino, et al.
Publicado: (2018)

IL-17 and IL-17-producing cells in protection versus pathology
por: Mills, Kingston H. G.
Publicado: (2022)

Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD
por: Doe, Camille, et al.
Publicado: (2010)

IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology
por: Nies, Jasper F., et al.
Publicado: (2020)

The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer
por: Bastid, Jérémy, et al.
Publicado: (2020)

Dual inhibition of IL-17A and IL-17F in psoriatic disease
por: Iznardo, Helena, et al.
Publicado: (2021)

Regulatory effects of C5a on IL-17A, IL-17F, and IL-23
por: Grailer, Jamison J., et al.
Publicado: (2013)

Clinical Significance of IL-23 Regulating IL-17A and/or IL-17F Positive Th17 Cells in Chronic Periodontitis
por: Luo, Zhenhua, et al.
Publicado: (2014)

Bimekizumab for the treatment of moderate‐to‐severe plaque psoriasis: efficacy, safety, pharmacokinetics, pharmacodynamics and transcriptomics from a phase IIa, randomized, double‐blind multicentre study
por: Oliver, R., et al.
Publicado: (2021)

The Clinical Significance of Simultaneous IL-17A and IL-17F Blockade in Psoriasis Non-Responding to Anti-IL17A Therapy
por: Kokolakis, Georgios, et al.
Publicado: (2022)

ABD-Derived Protein Blockers of Human IL-17 Receptor A as Non-IgG Alternatives for Modulation of IL-17-Dependent Pro-Inflammatory Axis
por: Hlavničková, Marie, et al.
Publicado: (2018)

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
por: Qu, Ning, et al.
Publicado: (2013)

Involvement of IL17A, IL17F and IL23R Polymorphisms in Colorectal Cancer Therapy
por: Omrane, Inés, et al.
Publicado: (2015)

IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis
por: Pawlik, Andrzej, et al.
Publicado: (2016)

Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer
por: Chen, Zheng, et al.
Publicado: (2023)

Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization
por: Segueni, Noria, et al.
Publicado: (2016)

Early IL-17A Prevention Rather Than Late IL-17A Neutralization Attenuates Toluene Diisocyanate-Induced Mixed Granulocytic Asthma
por: Chen, Shuyu, et al.
Publicado: (2022)

Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid
por: Nesmond, Stéphane, et al.
Publicado: (2019)

IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis
por: Bogunia-Kubik, Katarzyna, et al.
Publicado: (2014)

The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases
por: Navarro-Compán, Victoria, et al.
Publicado: (2023)

IL-17 propels infection
por: Maxmen, Amy
Publicado: (2009)

IL-17's tumor team
por: Maxmen, Amy
Publicado: (2009)

Antibodies attack IL-17
por: Maxmen, Amy
Publicado: (2010)

High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma
por: Liao, Rui, et al.
Publicado: (2013)

The Expression of Notch/Notch Ligand, IL-35, IL-17, and Th17/Treg in Preeclampsia
por: Cao, Weiping, et al.
Publicado: (2015)

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
por: Liu, Shenping, et al.
Publicado: (2016)

IL17eScan: A Tool for the Identification of Peptides Inducing IL-17 Response
por: Gupta, Sudheer, et al.
Publicado: (2017)

Pathogenic Role of IL-17 and Therapeutic Targeting of IL-17F in Psoriatic Arthritis and Spondyloarthropathies
por: Sánchez-Rodríguez, Guillermo, et al.
Publicado: (2023)

Targeting IL-17B–IL-17RB signaling with an anti–IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines
por: Wu, Heng-Hsiung, et al.
Publicado: (2015)

IL-17A, IL-17E and IL-17F as Potential Biomarkers for the Intensity of Low-Grade Inflammation and the Risk of Cardiovascular Diseases in Obese People
por: Polak-Szczybyło, Ewelina, et al.
Publicado: (2022)

The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A
por: Fu, Jiajia, et al.
Publicado: (2022)

Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
por: Shaw, Stevan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jqtftup5lemvbqoah8tp07tsjj