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An epidemiological modelling approach for COVID-19 via data assimilation

The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational d...

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Autores principales: Nadler, Philip, Wang, Shuo, Arcucci, Rossella, Yang, Xian, Guo, Yike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473594/
https://www.ncbi.nlm.nih.gov/pubmed/32888169
http://dx.doi.org/10.1007/s10654-020-00676-7
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author Nadler, Philip
Wang, Shuo
Arcucci, Rossella
Yang, Xian
Guo, Yike
author_facet Nadler, Philip
Wang, Shuo
Arcucci, Rossella
Yang, Xian
Guo, Yike
author_sort Nadler, Philip
collection PubMed
description The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational data assimilation. We analyze and discuss infection rates in the UK, US and Italy. We furthermore develop a custom compartmental SIR model fit to variables related to the available data of the pandemic, named SITR model, which allows for more granular inference on infection numbers. We compare and discuss model results which conducts updates as new observations become available. A hybrid data assimilation approach is applied to make results robust to initial conditions and measurement errors in the data. We use the model to conduct inference on infection numbers as well as parameters such as the disease transmissibility rate or the rate of recovery. The parameterisation of the model is parsimonious and extendable, allowing for the incorporation of additional data and parameters of interest. This allows for scalability and the extension of the model to other locations or the adaption of novel data sources.
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spelling pubmed-74735942020-09-08 An epidemiological modelling approach for COVID-19 via data assimilation Nadler, Philip Wang, Shuo Arcucci, Rossella Yang, Xian Guo, Yike Eur J Epidemiol Covid-19 The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational data assimilation. We analyze and discuss infection rates in the UK, US and Italy. We furthermore develop a custom compartmental SIR model fit to variables related to the available data of the pandemic, named SITR model, which allows for more granular inference on infection numbers. We compare and discuss model results which conducts updates as new observations become available. A hybrid data assimilation approach is applied to make results robust to initial conditions and measurement errors in the data. We use the model to conduct inference on infection numbers as well as parameters such as the disease transmissibility rate or the rate of recovery. The parameterisation of the model is parsimonious and extendable, allowing for the incorporation of additional data and parameters of interest. This allows for scalability and the extension of the model to other locations or the adaption of novel data sources. Springer Netherlands 2020-09-04 2020 /pmc/articles/PMC7473594/ /pubmed/32888169 http://dx.doi.org/10.1007/s10654-020-00676-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Covid-19
Nadler, Philip
Wang, Shuo
Arcucci, Rossella
Yang, Xian
Guo, Yike
An epidemiological modelling approach for COVID-19 via data assimilation
title An epidemiological modelling approach for COVID-19 via data assimilation
title_full An epidemiological modelling approach for COVID-19 via data assimilation
title_fullStr An epidemiological modelling approach for COVID-19 via data assimilation
title_full_unstemmed An epidemiological modelling approach for COVID-19 via data assimilation
title_short An epidemiological modelling approach for COVID-19 via data assimilation
title_sort epidemiological modelling approach for covid-19 via data assimilation
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473594/
https://www.ncbi.nlm.nih.gov/pubmed/32888169
http://dx.doi.org/10.1007/s10654-020-00676-7
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