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An epidemiological modelling approach for COVID-19 via data assimilation
The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473594/ https://www.ncbi.nlm.nih.gov/pubmed/32888169 http://dx.doi.org/10.1007/s10654-020-00676-7 |
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author | Nadler, Philip Wang, Shuo Arcucci, Rossella Yang, Xian Guo, Yike |
author_facet | Nadler, Philip Wang, Shuo Arcucci, Rossella Yang, Xian Guo, Yike |
author_sort | Nadler, Philip |
collection | PubMed |
description | The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational data assimilation. We analyze and discuss infection rates in the UK, US and Italy. We furthermore develop a custom compartmental SIR model fit to variables related to the available data of the pandemic, named SITR model, which allows for more granular inference on infection numbers. We compare and discuss model results which conducts updates as new observations become available. A hybrid data assimilation approach is applied to make results robust to initial conditions and measurement errors in the data. We use the model to conduct inference on infection numbers as well as parameters such as the disease transmissibility rate or the rate of recovery. The parameterisation of the model is parsimonious and extendable, allowing for the incorporation of additional data and parameters of interest. This allows for scalability and the extension of the model to other locations or the adaption of novel data sources. |
format | Online Article Text |
id | pubmed-7473594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-74735942020-09-08 An epidemiological modelling approach for COVID-19 via data assimilation Nadler, Philip Wang, Shuo Arcucci, Rossella Yang, Xian Guo, Yike Eur J Epidemiol Covid-19 The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational data assimilation. We analyze and discuss infection rates in the UK, US and Italy. We furthermore develop a custom compartmental SIR model fit to variables related to the available data of the pandemic, named SITR model, which allows for more granular inference on infection numbers. We compare and discuss model results which conducts updates as new observations become available. A hybrid data assimilation approach is applied to make results robust to initial conditions and measurement errors in the data. We use the model to conduct inference on infection numbers as well as parameters such as the disease transmissibility rate or the rate of recovery. The parameterisation of the model is parsimonious and extendable, allowing for the incorporation of additional data and parameters of interest. This allows for scalability and the extension of the model to other locations or the adaption of novel data sources. Springer Netherlands 2020-09-04 2020 /pmc/articles/PMC7473594/ /pubmed/32888169 http://dx.doi.org/10.1007/s10654-020-00676-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Covid-19 Nadler, Philip Wang, Shuo Arcucci, Rossella Yang, Xian Guo, Yike An epidemiological modelling approach for COVID-19 via data assimilation |
title | An epidemiological modelling approach for COVID-19 via data assimilation |
title_full | An epidemiological modelling approach for COVID-19 via data assimilation |
title_fullStr | An epidemiological modelling approach for COVID-19 via data assimilation |
title_full_unstemmed | An epidemiological modelling approach for COVID-19 via data assimilation |
title_short | An epidemiological modelling approach for COVID-19 via data assimilation |
title_sort | epidemiological modelling approach for covid-19 via data assimilation |
topic | Covid-19 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473594/ https://www.ncbi.nlm.nih.gov/pubmed/32888169 http://dx.doi.org/10.1007/s10654-020-00676-7 |
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