Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that TbAQP2’s unique architecture permits pentamidine...

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Detalles Bibliográficos
Autores principales: Alghamdi, Ali H, Munday, Jane C, Campagnaro, Gustavo Daniel, Gurvic, Dominik, Svensson, Fredrik, Okpara, Chinyere E, Kumar, Arvind, Quintana, Juan, Martin Abril, Maria Esther, Milić, Patrik, Watson, Laura, Paape, Daniel, Settimo, Luca, Dimitriou, Anna, Wielinska, Joanna, Smart, Graeme, Anderson, Laura F, Woodley, Christopher M, Kelly, Siu Pui Ying, Ibrahim, Hasan MS, Hulpia, Fabian, Al-Salabi, Mohammed I, Eze, Anthonius A, Sprenger, Teresa, Teka, Ibrahim A, Gudin, Simon, Weyand, Simone, Field, Mark, Dardonville, Christophe, Tidwell, Richard R, Carrington, Mark, O'Neill, Paul, Boykin, David W, Zachariae, Ulrich, De Koning, Harry P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473772/
https://www.ncbi.nlm.nih.gov/pubmed/32762841
http://dx.doi.org/10.7554/eLife.56416

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