Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis

Hexanucleotide repeat expansion of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Synergies between loss of C9ORF72 functions and gain of toxicities from the repeat expansions contribute to C9ORF72-mediated pathogenesis. However, how loss of C9...

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Detalles Bibliográficos
Autores principales: Ho, Wan Yun, Navakkode, Sheeja, Liu, Fujia, Soong, Tuck Wah, Ling, Shuo-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473815/
https://www.ncbi.nlm.nih.gov/pubmed/32887666
http://dx.doi.org/10.1186/s40478-020-01030-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473815/
https://www.ncbi.nlm.nih.gov/pubmed/32887666
http://dx.doi.org/10.1186/s40478-020-01030-4

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