A dopaminergic mechanism of antipsychotic drug efficacy, failure, and failure reversal: the role of the dopamine transporter

Antipsychotic drugs are effective interventions in schizophrenia. However, the efficacy of these agents often decreases over time, which leads to treatment failure and symptom recurrence. We report that antipsychotic efficacy in rat models declines in concert with extracellular striatal dopamine lev...

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Detalles Bibliográficos
Autores principales: Amato, Davide, Canneva, Fabio, Cumming, Paul, Maschauer, Simone, Groos, Dominik, Dahlmanns, Jana Katharina, Grömer, Teja W., Chiofalo, Lisa, Dahlmanns, Marc, Zheng, Fang, Kornhuber, Johannes, Prante, Olaf, Alzheimer, Christian, von Hörsten, Stephan, Müller, Christian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473845/
https://www.ncbi.nlm.nih.gov/pubmed/30038229
http://dx.doi.org/10.1038/s41380-018-0114-5

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