Cargando…

Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes

BACKGROUND: The association between coronary artery disease (CAD) and diabetes mellitus (DM) is strong but the physiologic mechanisms responsible for this association remain unclear. Patients with DM exhibit high circulating levels of glycated proteins and lipoproteins called advanced glycation end...

Descripción completa

Detalles Bibliográficos
Autores principales: Basman, Craig, Fishman, Sarah L., Avtanski, Dimiter, Rashid, Umar, Kodra, Arber, Chen, Karin, Jonas, Rebecca, Stoffels, Guillaume J., Lesser, Martin, Inlall, Damian, Ziskovich, Karina, Singh, Varinder, Poretsky, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474000/
https://www.ncbi.nlm.nih.gov/pubmed/32924001
http://dx.doi.org/10.1016/j.metop.2020.100050
_version_ 1783579266410086400
author Basman, Craig
Fishman, Sarah L.
Avtanski, Dimiter
Rashid, Umar
Kodra, Arber
Chen, Karin
Jonas, Rebecca
Stoffels, Guillaume J.
Lesser, Martin
Inlall, Damian
Ziskovich, Karina
Singh, Varinder
Poretsky, Leonid
author_facet Basman, Craig
Fishman, Sarah L.
Avtanski, Dimiter
Rashid, Umar
Kodra, Arber
Chen, Karin
Jonas, Rebecca
Stoffels, Guillaume J.
Lesser, Martin
Inlall, Damian
Ziskovich, Karina
Singh, Varinder
Poretsky, Leonid
author_sort Basman, Craig
collection PubMed
description BACKGROUND: The association between coronary artery disease (CAD) and diabetes mellitus (DM) is strong but the physiologic mechanisms responsible for this association remain unclear. Patients with DM exhibit high circulating levels of glycated proteins and lipoproteins called advanced glycation end products (AGEs) which have been implicated in the development of oxidative damage to vascular endothelium. We examined the relationships between the presence and extent of CAD and AGEs in patients undergoing elective coronary artery catheterization in an urban teaching hospital. METHODS: Patients with possible CAD (n = 364) were recruited prior to elective cardiac catheterization (52% male, 48% diabetic). Regression and correlation analyses were used to examine the relationship between serum AGE concentrations, soluble AGE receptor (sRAGE) concentration, HbA(1c), LDL and the presence of obstructive CAD along with the burden of CAD measured by SYNTAX and SYNTAX II scores. RESULTS: AGE and sRAGE levels did not significantly correlate with any of the studied coronary artery disease parameters. HbA(1c) showed positive correlation with both SYNTAX and SYNTAX II scores in patients with and without diabetes. CONCLUSION: In this cross-sectional study of patients with possible CAD, serum AGEs and sRAGE concentrations did not correlate with SYNTAX or SYNTAX II scores regardless of diabetic status. HbA1C correlated positively with the SYNTAX and SYNTAX II scores in both diabetic and non-diabetic populations.
format Online
Article
Text
id pubmed-7474000
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-74740002020-09-11 Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes Basman, Craig Fishman, Sarah L. Avtanski, Dimiter Rashid, Umar Kodra, Arber Chen, Karin Jonas, Rebecca Stoffels, Guillaume J. Lesser, Martin Inlall, Damian Ziskovich, Karina Singh, Varinder Poretsky, Leonid Metabol Open Original Research Paper BACKGROUND: The association between coronary artery disease (CAD) and diabetes mellitus (DM) is strong but the physiologic mechanisms responsible for this association remain unclear. Patients with DM exhibit high circulating levels of glycated proteins and lipoproteins called advanced glycation end products (AGEs) which have been implicated in the development of oxidative damage to vascular endothelium. We examined the relationships between the presence and extent of CAD and AGEs in patients undergoing elective coronary artery catheterization in an urban teaching hospital. METHODS: Patients with possible CAD (n = 364) were recruited prior to elective cardiac catheterization (52% male, 48% diabetic). Regression and correlation analyses were used to examine the relationship between serum AGE concentrations, soluble AGE receptor (sRAGE) concentration, HbA(1c), LDL and the presence of obstructive CAD along with the burden of CAD measured by SYNTAX and SYNTAX II scores. RESULTS: AGE and sRAGE levels did not significantly correlate with any of the studied coronary artery disease parameters. HbA(1c) showed positive correlation with both SYNTAX and SYNTAX II scores in patients with and without diabetes. CONCLUSION: In this cross-sectional study of patients with possible CAD, serum AGEs and sRAGE concentrations did not correlate with SYNTAX or SYNTAX II scores regardless of diabetic status. HbA1C correlated positively with the SYNTAX and SYNTAX II scores in both diabetic and non-diabetic populations. Elsevier 2020-08-16 /pmc/articles/PMC7474000/ /pubmed/32924001 http://dx.doi.org/10.1016/j.metop.2020.100050 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Paper
Basman, Craig
Fishman, Sarah L.
Avtanski, Dimiter
Rashid, Umar
Kodra, Arber
Chen, Karin
Jonas, Rebecca
Stoffels, Guillaume J.
Lesser, Martin
Inlall, Damian
Ziskovich, Karina
Singh, Varinder
Poretsky, Leonid
Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
title Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
title_full Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
title_fullStr Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
title_full_unstemmed Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
title_short Glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
title_sort glycosylated hemoglobin, but not advanced glycation end products, predicts severity of coronary artery disease in patients with or without diabetes
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474000/
https://www.ncbi.nlm.nih.gov/pubmed/32924001
http://dx.doi.org/10.1016/j.metop.2020.100050
work_keys_str_mv AT basmancraig glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT fishmansarahl glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT avtanskidimiter glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT rashidumar glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT kodraarber glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT chenkarin glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT jonasrebecca glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT stoffelsguillaumej glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT lessermartin glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT inlalldamian glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT ziskovichkarina glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT singhvarinder glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes
AT poretskyleonid glycosylatedhemoglobinbutnotadvancedglycationendproductspredictsseverityofcoronaryarterydiseaseinpatientswithorwithoutdiabetes