Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction in neurodegenerative diseases remain elusive. Here, we report zonation-dependent transcriptomic changes...

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Detalles Bibliográficos
Autores principales: Zhao, Lei, Li, Zhongqi, Vong, Joaquim S. L., Chen, Xinyi, Lai, Hei-Ming, Yan, Leo Y. C., Huang, Junzhe, Sy, Samuel K. H., Tian, Xiaoyu, Huang, Yu, Chan, Ho Yin Edwin, So, Hon-Cheong, Ng, Wai-Lung, Tang, Yamei, Lin, Wei-Jye, Mok, Vincent C. T., Ko, Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474063/
https://www.ncbi.nlm.nih.gov/pubmed/32887883
http://dx.doi.org/10.1038/s41467-020-18249-3

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